Abstract
Chromaffin cell γ-aminobutyric acid (GABA) receptors play a role in modulating catecholamine secretion. The present experiments examined the role of GABA receptors in modulation of tyrosine hydroxylase (TH) induction in rat adrenal gland. Administration of bicuculline, a GABA antagonist, had no effect on TH activity or TH mRNA. However, bicuculline potentiated reserpine's effect on TH activity and TH mRNA induction. These data suggest that GABA receptors modulate induction of TH and TH mRNA in the adrenal gland.
Original language | English (US) |
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Pages (from-to) | 175-180 |
Number of pages | 6 |
Journal | Neuroscience Letters |
Volume | 117 |
Issue number | 1-2 |
DOIs | |
State | Published - Sep 4 1990 |
Keywords
- Adrenal gland
- Bicuculline
- GABA
- Reserpine
- Tyrosine hydroxylase
- Tyrosine hydroxylase mRNA
ASJC Scopus subject areas
- General Neuroscience