GABA receptor modulation of tyrosine hydroxylase gene expression in the rat adrenal gland

R. Strong, C. Hale, M. A. Moore, M. Wessels-Reiker, H. J. Armbrecht, A. Richardson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Chromaffin cell γ-aminobutyric acid (GABA) receptors play a role in modulating catecholamine secretion. The present experiments examined the role of GABA receptors in modulation of tyrosine hydroxylase (TH) induction in rat adrenal gland. Administration of bicuculline, a GABA antagonist, had no effect on TH activity or TH mRNA. However, bicuculline potentiated reserpine's effect on TH activity and TH mRNA induction. These data suggest that GABA receptors modulate induction of TH and TH mRNA in the adrenal gland.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalNeuroscience Letters
Volume117
Issue number1-2
DOIs
StatePublished - Sep 4 1990

Keywords

  • Adrenal gland
  • Bicuculline
  • GABA
  • Reserpine
  • Tyrosine hydroxylase
  • Tyrosine hydroxylase mRNA

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'GABA receptor modulation of tyrosine hydroxylase gene expression in the rat adrenal gland'. Together they form a unique fingerprint.

Cite this