G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase a-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production

Stefan Broselid, Kelly A. Berg, Teresa A. Chavera, Robin Kahn, William P. Clarke, Björn Olde, L. M.Fredrik Leeb-Lundberg

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Background: GPR30 plays important roles in cardiometabolic regulation and cancer. Results: GPR30 forms a complex with a MAGUK and AKAP5 that constitutively inhibits cAMP production independently of Gi/o and retains receptors in the plasma membrane. Conclusion: The GPR30-MAGUK-AKAP5 complex mediates receptor signaling. Significance: These results present a new mechanism by which a receptor inhibits cAMP production.

Original languageEnglish (US)
Pages (from-to)22117-22127
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - Aug 8 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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