G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase a-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production

Stefan Broselid; Kelly A. Berg; Teresa A. Chavera; Robin Kahn; William P. Clarke; Björn Olde; L. M.Fredrik Leeb-Lundberg

doi:10.1074/jbc.M114.566893

G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase a-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production

Stefan Broselid, Kelly A. Berg, Teresa A. Chavera, Robin Kahn, William P. Clarke, Björn Olde, L. M.Fredrik Leeb-Lundberg

Department of Pharmacology

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Background: GPR30 plays important roles in cardiometabolic regulation and cancer. Results: GPR30 forms a complex with a MAGUK and AKAP5 that constitutively inhibits cAMP production independently of Gi/o and retains receptors in the plasma membrane. Conclusion: The GPR30-MAGUK-AKAP5 complex mediates receptor signaling. Significance: These results present a new mechanism by which a receptor inhibits cAMP production.

Original language	English (US)
Pages (from-to)	22117-22127
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.566893
State	Published - Aug 8 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Broselid, S., Berg, K. A., Chavera, T. A., Kahn, R., Clarke, W. P., Olde, B., & Leeb-Lundberg, L. M. F. (2014). G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase a-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production. Journal of Biological Chemistry, 289(32), 22117-22127. https://doi.org/10.1074/jbc.M114.566893

G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase a-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production. / Broselid, Stefan; Berg, Kelly A.; Chavera, Teresa A. et al.
In: Journal of Biological Chemistry, Vol. 289, No. 32, 08.08.2014, p. 22117-22127.

Research output: Contribution to journal › Article › peer-review

Broselid, S, Berg, KA, Chavera, TA, Kahn, R, Clarke, WP, Olde, B & Leeb-Lundberg, LMF 2014, 'G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase a-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production', Journal of Biological Chemistry, vol. 289, no. 32, pp. 22117-22127. https://doi.org/10.1074/jbc.M114.566893

Broselid S, Berg KA, Chavera TA, Kahn R, Clarke WP, Olde B et al. G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase a-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production. Journal of Biological Chemistry. 2014 Aug 8;289(32):22117-22127. doi: 10.1074/jbc.M114.566893

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G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase a-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production

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