Gβ5 is required for normal light responses and morphology of retinal ON-bipolar cells

Anjali Rao, Rebecca Dallman, Scott Henderson, Ching Kang Jason Chen

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Gβ5 exists as two splice variants, Gβ5-S and Gβ5-L, which interact with and stabilize the R7 members of the regulators of G-protein signaling (RGSs): RGS6, RGS7, RGS9, and RGS11. Although the role of Gβ5-L and RGS9-1 is established in photoreceptors, the physiological functions of Gβ5-S and other R7 RGS proteins remain unclear. We found that the electroretinogram of Gβ5-/- mice lacks the b-wave component and that Gβ5-S and RGS11 colocalize with Goα at the tips of the ON-bipolar cell dendrites. Unexpectedly, we found a significant reduction in the number of synaptic triads in the outer plexiform layer (OPL) of the Gβ5-/- mice, which is evident at postnatal day 14. Transgenic expression of Gβ5-L in rods failed to rescue the b-wave or the OPL defects. These results indicate that Gβ5-S is indispensable for OPL integrity and normal light responses of the retina.

Original languageEnglish (US)
Pages (from-to)14199-14204
Number of pages6
JournalJournal of Neuroscience
Issue number51
StatePublished - Dec 19 2007
Externally publishedYes


  • Bipolar cells
  • ERG
  • Gβ5
  • Morphology
  • RGS
  • Retina

ASJC Scopus subject areas

  • General Neuroscience


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