Future research directions in pneumonia

Charles S. Dela Cruz, Richard G. Wunderink, David C. Christiani, Stephania A. Cormier, Kristina Crothers, Claire M. Doerschuk, Scott E. Evans, Daniel R. Goldstein, Purvesh Khatri, Lester Kobzik, Jay K. Kolls, Bruce D. Levy, Mark L. Metersky, Michael S. Niederman, Roomi Nusrat, Carlos J. Orihuela, Paula Peyrani, Alice S. Prince, Julio A. Ramírez, Karen M. RidgeSanjay Sethi, Benjamin T. Suratt, Jacob I. Sznajder, Ephraim L. Tsalik, Allan J. Walkey, Sachin Yende, Neil R. Aggarwal, Elisabet V. Caler, Joseph P. Mizgerd

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Pneumonia is a complex pulmonary disease in need of new clinical approaches. Although triggered by a pathogen, pneumonia often results from dysregulations of host defense that likely precede infection. The coordinated activities of immune resistance and tissue resilience then dictate whether and how pneumonia progresses or resolves. Inadequate or inappropriate host responses lead to more severe outcomes such as acute respiratory distress syndrome and to organ dysfunction beyond the lungs and over extended time frames after pathogen clearance, some of which increase the risk for subsequent pneumonia. Improved understanding of such host responses will guide the development of novel approaches for preventing and curing pneumonia and for mitigating the subsequent pulmonary and extrapulmonary complications of pneumonia. The NHLBI assembled a working group of extramural investigators to prioritize avenues of host-directed pneumonia research that should yield novel approaches for interrupting the cycle of unhealthy decline caused by pneumonia. This report summarizes the working group’s specific recommendations in the areas of pneumonia susceptibility, host response, and consequences. Overarching goals include the development of more host-focused clinical approaches for preventing and treating pneumonia, the generation of predictive tools (for pneumonia occurrence, severity, and outcome), and the elucidation of mechanisms mediating immune resistance and tissue resilience in the lung. Specific areas of research are highlighted as especially promising for making advances against pneumonia.

Original languageEnglish (US)
Pages (from-to)256-263
Number of pages8
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume198
Issue number2
DOIs
StatePublished - Jul 15 2018
Externally publishedYes

Fingerprint

Pneumonia
Lung
Direction compound
National Heart, Lung, and Blood Institute (U.S.)
Adult Respiratory Distress Syndrome
Research
Lung Diseases
Research Personnel
Infection

Keywords

  • Bacterial infection
  • Host response
  • Host susceptibility
  • Pneumonia
  • Viral infection

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Dela Cruz, C. S., Wunderink, R. G., Christiani, D. C., Cormier, S. A., Crothers, K., Doerschuk, C. M., ... Mizgerd, J. P. (2018). Future research directions in pneumonia. American Journal of Respiratory and Critical Care Medicine, 198(2), 256-263. https://doi.org/10.1164/rccm.201801-0139WS

Future research directions in pneumonia. / Dela Cruz, Charles S.; Wunderink, Richard G.; Christiani, David C.; Cormier, Stephania A.; Crothers, Kristina; Doerschuk, Claire M.; Evans, Scott E.; Goldstein, Daniel R.; Khatri, Purvesh; Kobzik, Lester; Kolls, Jay K.; Levy, Bruce D.; Metersky, Mark L.; Niederman, Michael S.; Nusrat, Roomi; Orihuela, Carlos J.; Peyrani, Paula; Prince, Alice S.; Ramírez, Julio A.; Ridge, Karen M.; Sethi, Sanjay; Suratt, Benjamin T.; Sznajder, Jacob I.; Tsalik, Ephraim L.; Walkey, Allan J.; Yende, Sachin; Aggarwal, Neil R.; Caler, Elisabet V.; Mizgerd, Joseph P.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 198, No. 2, 15.07.2018, p. 256-263.

Research output: Contribution to journalArticle

Dela Cruz, CS, Wunderink, RG, Christiani, DC, Cormier, SA, Crothers, K, Doerschuk, CM, Evans, SE, Goldstein, DR, Khatri, P, Kobzik, L, Kolls, JK, Levy, BD, Metersky, ML, Niederman, MS, Nusrat, R, Orihuela, CJ, Peyrani, P, Prince, AS, Ramírez, JA, Ridge, KM, Sethi, S, Suratt, BT, Sznajder, JI, Tsalik, EL, Walkey, AJ, Yende, S, Aggarwal, NR, Caler, EV & Mizgerd, JP 2018, 'Future research directions in pneumonia', American Journal of Respiratory and Critical Care Medicine, vol. 198, no. 2, pp. 256-263. https://doi.org/10.1164/rccm.201801-0139WS
Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM et al. Future research directions in pneumonia. American Journal of Respiratory and Critical Care Medicine. 2018 Jul 15;198(2):256-263. https://doi.org/10.1164/rccm.201801-0139WS
Dela Cruz, Charles S. ; Wunderink, Richard G. ; Christiani, David C. ; Cormier, Stephania A. ; Crothers, Kristina ; Doerschuk, Claire M. ; Evans, Scott E. ; Goldstein, Daniel R. ; Khatri, Purvesh ; Kobzik, Lester ; Kolls, Jay K. ; Levy, Bruce D. ; Metersky, Mark L. ; Niederman, Michael S. ; Nusrat, Roomi ; Orihuela, Carlos J. ; Peyrani, Paula ; Prince, Alice S. ; Ramírez, Julio A. ; Ridge, Karen M. ; Sethi, Sanjay ; Suratt, Benjamin T. ; Sznajder, Jacob I. ; Tsalik, Ephraim L. ; Walkey, Allan J. ; Yende, Sachin ; Aggarwal, Neil R. ; Caler, Elisabet V. ; Mizgerd, Joseph P. / Future research directions in pneumonia. In: American Journal of Respiratory and Critical Care Medicine. 2018 ; Vol. 198, No. 2. pp. 256-263.
@article{5e19162a39cb41e28a3365382a5a82d3,
title = "Future research directions in pneumonia",
abstract = "Pneumonia is a complex pulmonary disease in need of new clinical approaches. Although triggered by a pathogen, pneumonia often results from dysregulations of host defense that likely precede infection. The coordinated activities of immune resistance and tissue resilience then dictate whether and how pneumonia progresses or resolves. Inadequate or inappropriate host responses lead to more severe outcomes such as acute respiratory distress syndrome and to organ dysfunction beyond the lungs and over extended time frames after pathogen clearance, some of which increase the risk for subsequent pneumonia. Improved understanding of such host responses will guide the development of novel approaches for preventing and curing pneumonia and for mitigating the subsequent pulmonary and extrapulmonary complications of pneumonia. The NHLBI assembled a working group of extramural investigators to prioritize avenues of host-directed pneumonia research that should yield novel approaches for interrupting the cycle of unhealthy decline caused by pneumonia. This report summarizes the working group’s specific recommendations in the areas of pneumonia susceptibility, host response, and consequences. Overarching goals include the development of more host-focused clinical approaches for preventing and treating pneumonia, the generation of predictive tools (for pneumonia occurrence, severity, and outcome), and the elucidation of mechanisms mediating immune resistance and tissue resilience in the lung. Specific areas of research are highlighted as especially promising for making advances against pneumonia.",
keywords = "Bacterial infection, Host response, Host susceptibility, Pneumonia, Viral infection",
author = "{Dela Cruz}, {Charles S.} and Wunderink, {Richard G.} and Christiani, {David C.} and Cormier, {Stephania A.} and Kristina Crothers and Doerschuk, {Claire M.} and Evans, {Scott E.} and Goldstein, {Daniel R.} and Purvesh Khatri and Lester Kobzik and Kolls, {Jay K.} and Levy, {Bruce D.} and Metersky, {Mark L.} and Niederman, {Michael S.} and Roomi Nusrat and Orihuela, {Carlos J.} and Paula Peyrani and Prince, {Alice S.} and Ram{\'i}rez, {Julio A.} and Ridge, {Karen M.} and Sanjay Sethi and Suratt, {Benjamin T.} and Sznajder, {Jacob I.} and Tsalik, {Ephraim L.} and Walkey, {Allan J.} and Sachin Yende and Aggarwal, {Neil R.} and Caler, {Elisabet V.} and Mizgerd, {Joseph P.}",
year = "2018",
month = "7",
day = "15",
doi = "10.1164/rccm.201801-0139WS",
language = "English (US)",
volume = "198",
pages = "256--263",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "2",

}

TY - JOUR

T1 - Future research directions in pneumonia

AU - Dela Cruz, Charles S.

AU - Wunderink, Richard G.

AU - Christiani, David C.

AU - Cormier, Stephania A.

AU - Crothers, Kristina

AU - Doerschuk, Claire M.

AU - Evans, Scott E.

AU - Goldstein, Daniel R.

AU - Khatri, Purvesh

AU - Kobzik, Lester

AU - Kolls, Jay K.

AU - Levy, Bruce D.

AU - Metersky, Mark L.

AU - Niederman, Michael S.

AU - Nusrat, Roomi

AU - Orihuela, Carlos J.

AU - Peyrani, Paula

AU - Prince, Alice S.

AU - Ramírez, Julio A.

AU - Ridge, Karen M.

AU - Sethi, Sanjay

AU - Suratt, Benjamin T.

AU - Sznajder, Jacob I.

AU - Tsalik, Ephraim L.

AU - Walkey, Allan J.

AU - Yende, Sachin

AU - Aggarwal, Neil R.

AU - Caler, Elisabet V.

AU - Mizgerd, Joseph P.

PY - 2018/7/15

Y1 - 2018/7/15

N2 - Pneumonia is a complex pulmonary disease in need of new clinical approaches. Although triggered by a pathogen, pneumonia often results from dysregulations of host defense that likely precede infection. The coordinated activities of immune resistance and tissue resilience then dictate whether and how pneumonia progresses or resolves. Inadequate or inappropriate host responses lead to more severe outcomes such as acute respiratory distress syndrome and to organ dysfunction beyond the lungs and over extended time frames after pathogen clearance, some of which increase the risk for subsequent pneumonia. Improved understanding of such host responses will guide the development of novel approaches for preventing and curing pneumonia and for mitigating the subsequent pulmonary and extrapulmonary complications of pneumonia. The NHLBI assembled a working group of extramural investigators to prioritize avenues of host-directed pneumonia research that should yield novel approaches for interrupting the cycle of unhealthy decline caused by pneumonia. This report summarizes the working group’s specific recommendations in the areas of pneumonia susceptibility, host response, and consequences. Overarching goals include the development of more host-focused clinical approaches for preventing and treating pneumonia, the generation of predictive tools (for pneumonia occurrence, severity, and outcome), and the elucidation of mechanisms mediating immune resistance and tissue resilience in the lung. Specific areas of research are highlighted as especially promising for making advances against pneumonia.

AB - Pneumonia is a complex pulmonary disease in need of new clinical approaches. Although triggered by a pathogen, pneumonia often results from dysregulations of host defense that likely precede infection. The coordinated activities of immune resistance and tissue resilience then dictate whether and how pneumonia progresses or resolves. Inadequate or inappropriate host responses lead to more severe outcomes such as acute respiratory distress syndrome and to organ dysfunction beyond the lungs and over extended time frames after pathogen clearance, some of which increase the risk for subsequent pneumonia. Improved understanding of such host responses will guide the development of novel approaches for preventing and curing pneumonia and for mitigating the subsequent pulmonary and extrapulmonary complications of pneumonia. The NHLBI assembled a working group of extramural investigators to prioritize avenues of host-directed pneumonia research that should yield novel approaches for interrupting the cycle of unhealthy decline caused by pneumonia. This report summarizes the working group’s specific recommendations in the areas of pneumonia susceptibility, host response, and consequences. Overarching goals include the development of more host-focused clinical approaches for preventing and treating pneumonia, the generation of predictive tools (for pneumonia occurrence, severity, and outcome), and the elucidation of mechanisms mediating immune resistance and tissue resilience in the lung. Specific areas of research are highlighted as especially promising for making advances against pneumonia.

KW - Bacterial infection

KW - Host response

KW - Host susceptibility

KW - Pneumonia

KW - Viral infection

UR - http://www.scopus.com/inward/record.url?scp=85048936786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048936786&partnerID=8YFLogxK

U2 - 10.1164/rccm.201801-0139WS

DO - 10.1164/rccm.201801-0139WS

M3 - Article

AN - SCOPUS:85048936786

VL - 198

SP - 256

EP - 263

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 2

ER -