Future perspective on host-pathogen interactions during bacterial biofilm formation within the nasopharynx

Krystle A. Blanchette, Carlos J. Orihuela

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Nasopharyngeal colonization provides bacteria with a place of residence, a platform for person-to-person transmission and for many opportunistic pathogens it is a prerequisite event towards the development of invasive disease. Therefore, how host factors within the nasopharynx contribute to, inhibit or otherwise shape biofilm formation, the primary mode of existence for colonizing bacteria, and how biofilm bacteria subvert the acute inflammatory response that facilitates clearance, are important topics for future microbiological research. This review proposes the examination of host components as bridging molecules for bacterial interactions during biofilm formation, altered virulence determinant production and cell wall modification as a mechanism for immunoquiescence, and the role of host factors as signals and co-opted mechanisms for bacterial dissemination, together providing an opportunity for disease.

Original languageEnglish (US)
Pages (from-to)227-239
Number of pages13
JournalFuture Microbiology
Volume7
Issue number2
DOIs
StatePublished - Feb 2012

Keywords

  • asymptomatic carriage
  • bacteria
  • biofilm
  • colonization
  • nasopharynx
  • persistence

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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