Future of genetics of mood disorders research

Kathleen R. Merikangas, Aravinda Chakravarti, Steven O. Moldin, Houmam Araj, John Blangero, Margit Burmeister, John C. Crabbe, J. Raymond Depaulo, Edward Foulks, Nelson B. Freimer, Doreen S. Koretz, William Lichtenstein, Emmanuel Mignot, Allan L. Reiss, Neil J. Risch, Joseph S. Takahashi

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

This report summarizes the deliberations of a panel with representation from diverse disciplines of relevance to the genetics of mood disorders. The major charge to the panel was to develop a strategic plan to employ the tools of genetics to advance the understanding, treatment, and outcomes for mood disorders. A comprehensive review of the evidence for the role of genetic factors in the etiology of mood disorders was conducted, and the chief impediments for progress in gene identification were identified. The National Institute of Mental Health (NIMH) portfolios in the Genetics Research Branch and the Division of Mental Disorders, Behavioral Sciences, AIDS, and all genetics training activities were reviewed. Despite some promising leads, there are still no confirmed linkage findings for mood disorders. Impediments to gene finding include the lack of phenotypic validity, variation in ascertainment sources and methodology across studies, and genetic complexity. With respect to linkage, the committee recommended that a large-scale, integrated effort be undertaken to examine existing data from linkage and association studies of bipolar disorders using identical phenotypes and statistical methods across studies to determine whether the suggestive linkage findings at some loci can be confirmed. Confirmation would justify more intensive approaches to gene finding. The committee recommended that the NIMH support continued efforts to identify the most heritable subtypes and endophenotypes of major depression using the tools of genetic epidemiology, neuroscience, and behavioral science. The field of genetic epidemiology was identified as an important future direction because population-based, epidemiologic studies of families and unrelated affected individuals assume increasing importance for common chronic diseases. To prepare for shifts to more complex genetic models, the committee recommended that the NIMH develop new interdisciplinary training strategies to prepare for the next generation of genetics research.

Original languageEnglish (US)
Pages (from-to)457-477
Number of pages21
JournalBiological Psychiatry
Volume52
Issue number6
DOIs
StatePublished - Sep 15 2002
Externally publishedYes

Fingerprint

Inborn Genetic Diseases
National Institute of Mental Health (U.S.)
Mood Disorders
Behavioral Sciences
Genetic Research
Molecular Epidemiology
Research
Genes
Endophenotypes
Information Storage and Retrieval
Genetic Models
Neurosciences
Bipolar Disorder
Mental Disorders
Epidemiologic Studies
Teaching
Acquired Immunodeficiency Syndrome
Chronic Disease
Depression
Phenotype

Keywords

  • Epidemiology
  • Genetics
  • Linkage
  • Mood disorders
  • Training

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Merikangas, K. R., Chakravarti, A., Moldin, S. O., Araj, H., Blangero, J., Burmeister, M., ... Takahashi, J. S. (2002). Future of genetics of mood disorders research. Biological Psychiatry, 52(6), 457-477. https://doi.org/10.1016/S0006-3223(02)01471-3

Future of genetics of mood disorders research. / Merikangas, Kathleen R.; Chakravarti, Aravinda; Moldin, Steven O.; Araj, Houmam; Blangero, John; Burmeister, Margit; Crabbe, John C.; Depaulo, J. Raymond; Foulks, Edward; Freimer, Nelson B.; Koretz, Doreen S.; Lichtenstein, William; Mignot, Emmanuel; Reiss, Allan L.; Risch, Neil J.; Takahashi, Joseph S.

In: Biological Psychiatry, Vol. 52, No. 6, 15.09.2002, p. 457-477.

Research output: Contribution to journalArticle

Merikangas, KR, Chakravarti, A, Moldin, SO, Araj, H, Blangero, J, Burmeister, M, Crabbe, JC, Depaulo, JR, Foulks, E, Freimer, NB, Koretz, DS, Lichtenstein, W, Mignot, E, Reiss, AL, Risch, NJ & Takahashi, JS 2002, 'Future of genetics of mood disorders research', Biological Psychiatry, vol. 52, no. 6, pp. 457-477. https://doi.org/10.1016/S0006-3223(02)01471-3
Merikangas KR, Chakravarti A, Moldin SO, Araj H, Blangero J, Burmeister M et al. Future of genetics of mood disorders research. Biological Psychiatry. 2002 Sep 15;52(6):457-477. https://doi.org/10.1016/S0006-3223(02)01471-3
Merikangas, Kathleen R. ; Chakravarti, Aravinda ; Moldin, Steven O. ; Araj, Houmam ; Blangero, John ; Burmeister, Margit ; Crabbe, John C. ; Depaulo, J. Raymond ; Foulks, Edward ; Freimer, Nelson B. ; Koretz, Doreen S. ; Lichtenstein, William ; Mignot, Emmanuel ; Reiss, Allan L. ; Risch, Neil J. ; Takahashi, Joseph S. / Future of genetics of mood disorders research. In: Biological Psychiatry. 2002 ; Vol. 52, No. 6. pp. 457-477.
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