Future directions in the prevention of prostate cancer

Ian M. Thompson, April B. Cabang, Michael J. Wargovich

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

The high global incidence of prostate cancer has led to a focus on chemoprevention strategies to reduce the public health impact of the disease. Early studies indicating that selenium and vitamin E might protect against prostate cancer encouraged large-scale studies that produced mixed clinical results. Next-generation prostate cancer prevention trials validated the impact of 5α-reductase inhibitors in hormone-responsive prostate cancer, and these results were confirmed in follow-up studies. Other interventions on the horizon, involving both dietary and pharmacological agents, hold some promise but require further investigation to validate their efficacy. In this Review, we discuss the clinical and preclinical evidence for dietary and pharmacological prevention of prostate cancer and give an overview of future opportunities for chemoprevention.

Original languageEnglish (US)
Pages (from-to)49-60
Number of pages12
JournalNature Reviews Clinical Oncology
Volume11
Issue number1
DOIs
StatePublished - Jan 2014

ASJC Scopus subject areas

  • Oncology

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