Further Studies of Gastric Hypersecretion in Chronic Renal Failure

A. M.M. Shepherd, W. K. Stewart, B. Thjodleifsson, K. G. Wormsley

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The effect of medical treatment has been studied in four patients with end-stage renal failure who suffered from severe spontaneous gastric hypersecretion, associated with very low levels of intraduodenal pH in two cases. Atropine decreased the overnight gastric acid output, but the residual acid secretion and duodenal content of acid remained dangerously high in one of the patients. Secretin inhibited the basal gastric secretion of acid in all cases and converted the pH of the duodenal contents to alkaline. While atropine cannot be used to control the gastric hypersecretion, secretin may prove to be valuable in the therapeutic management of the gastric hypersecretion of patients with chronic renal failure.

Original languageEnglish (US)
Pages (from-to)96-98
Number of pages3
JournalBritish Medical Journal
Issue number5898
StatePublished - Jan 19 1974
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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