Further evidence of accelerated aging in bipolar disorder: Focus on GDF-15

Fang Yang; Izabela G. Barbosa; Erica L. Vieira; Moises E. Bauer; Natalia P. Rocha; Antonio L. Teixeira

doi:10.1515/tnsci-2018-0004

Further evidence of accelerated aging in bipolar disorder: Focus on GDF-15

Fang Yang, Izabela G. Barbosa, Erica L. Vieira, Moises E. Bauer, Natalia P. Rocha, Antonio L. Teixeira

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters. Forty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study. Plasma levels of GDF-15 were measured by immunoassay. The levels of GDF-15 were significantly higher (p < 0.001) in patients with BD in comparison with controls. In patients, GDF-15 levels correlated with age (rho = 0.434; p = 0.003) and illness duration (rho = 0.502; p = 0.001). Our findings corroborate the view that BD is an illness associated with accelerated aging.

Original language	English (US)
Pages (from-to)	17-21
Number of pages	5
Journal	Translational Neuroscience
Volume	9
Issue number	1
DOIs	https://doi.org/10.1515/tnsci-2018-0004
State	Published - 2018
Externally published	Yes

Keywords

Aging
Bipolar disorder
GDF-15

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1515/tnsci-2018-0004

Cite this

@article{6913bfeca2e14aa4b45f028da3fc8adb,

title = "Further evidence of accelerated aging in bipolar disorder: Focus on GDF-15",

abstract = "Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters. Forty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study. Plasma levels of GDF-15 were measured by immunoassay. The levels of GDF-15 were significantly higher (p < 0.001) in patients with BD in comparison with controls. In patients, GDF-15 levels correlated with age (rho = 0.434; p = 0.003) and illness duration (rho = 0.502; p = 0.001). Our findings corroborate the view that BD is an illness associated with accelerated aging.",

keywords = "Aging, Bipolar disorder, GDF-15",

author = "Fang Yang and Barbosa, {Izabela G.} and Vieira, {Erica L.} and Bauer, {Moises E.} and Rocha, {Natalia P.} and Teixeira, {Antonio L.}",

note = "Publisher Copyright: {\textcopyright} 2018 2018 Fang Yang et al.",

year = "2018",

doi = "10.1515/tnsci-2018-0004",

language = "English (US)",

volume = "9",

pages = "17--21",

journal = "Translational Neuroscience",

issn = "2081-3856",

publisher = "Walter de Gruyter GmbH",

number = "1",

}

TY - JOUR

T1 - Further evidence of accelerated aging in bipolar disorder

T2 - Focus on GDF-15

AU - Yang, Fang

AU - Barbosa, Izabela G.

AU - Vieira, Erica L.

AU - Bauer, Moises E.

AU - Rocha, Natalia P.

AU - Teixeira, Antonio L.

PY - 2018

Y1 - 2018

N2 - Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters. Forty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study. Plasma levels of GDF-15 were measured by immunoassay. The levels of GDF-15 were significantly higher (p < 0.001) in patients with BD in comparison with controls. In patients, GDF-15 levels correlated with age (rho = 0.434; p = 0.003) and illness duration (rho = 0.502; p = 0.001). Our findings corroborate the view that BD is an illness associated with accelerated aging.

AB - Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters. Forty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study. Plasma levels of GDF-15 were measured by immunoassay. The levels of GDF-15 were significantly higher (p < 0.001) in patients with BD in comparison with controls. In patients, GDF-15 levels correlated with age (rho = 0.434; p = 0.003) and illness duration (rho = 0.502; p = 0.001). Our findings corroborate the view that BD is an illness associated with accelerated aging.

KW - Aging

KW - Bipolar disorder

KW - GDF-15

UR - http://www.scopus.com/inward/record.url?scp=85045042266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045042266&partnerID=8YFLogxK

U2 - 10.1515/tnsci-2018-0004

DO - 10.1515/tnsci-2018-0004

M3 - Article

AN - SCOPUS:85045042266

SN - 2081-3856

VL - 9

SP - 17

EP - 21

JO - Translational Neuroscience

JF - Translational Neuroscience

IS - 1

ER -

Further evidence of accelerated aging in bipolar disorder: Focus on GDF-15

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this