Further evidence of accelerated aging in bipolar disorder: Focus on GDF-15

Fang Yang, Izabela G. Barbosa, Erica L. Vieira, Moises E. Bauer, Natalia P. Rocha, Antonio L. Teixeira

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters. Forty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study. Plasma levels of GDF-15 were measured by immunoassay. The levels of GDF-15 were significantly higher (p < 0.001) in patients with BD in comparison with controls. In patients, GDF-15 levels correlated with age (rho = 0.434; p = 0.003) and illness duration (rho = 0.502; p = 0.001). Our findings corroborate the view that BD is an illness associated with accelerated aging.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalTranslational Neuroscience
Issue number1
StatePublished - 2018
Externally publishedYes


  • Aging
  • Bipolar disorder
  • GDF-15

ASJC Scopus subject areas

  • General Neuroscience


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