Fungal endophthalmitis caused by Aspergillus ustus in a patient following cataract surgery

Sinasi Taner Yildiran, Fatih Mehmet Mutlu, Mehmet Ali Saracli, Yusuf Uysal, Ahmet Gonlum, Gungor Sobaci, Deanna A. Sutton

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The first case of postoperative endophthalmitis after cataract surgery caused by Aspergillus ustus, a species that has only rarely been implicated in human disease, is described. Six weeks after cataract surgery, a 67-year-old medically controlled diabetic patient presented with uveitis, mild ciliary injection and ocular discomfort. Anterior chamber paracentesis, vitreous tap and finally complete vitrectomy with removal of the capsular bag including the intraocular lens were performed and several sets of culture yielded A. ustus. Despite vigorous systemic (itraconazole and caspofungin) and intravitreal (amphotericin B and caspofungin) antifungal therapy, the endophthalmitis did not improve. The painful eye with marked inflammation was finally enucleated. In vitro susceptibility testing of the isolate showed that it appeared resistant to amphotericin B, caspofungin, itraconazole, voriconazole, and posaconazole, and susceptible to terbinafine.

Original languageEnglish (US)
Pages (from-to)665-669
Number of pages5
JournalMedical mycology
Volume44
Issue number7
DOIs
StatePublished - Nov 2006

Keywords

  • Aspergillus ustus
  • Cataract surgery
  • Endophthalmitis

ASJC Scopus subject areas

  • Infectious Diseases

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