TY - JOUR
T1 - Fungal disease of the nose and sinuses
T2 - An updated overview
AU - Chang, Christopher
AU - Gershwin, M. Eric
AU - Thompson, George R.
N1 - Funding Information:
Acknowledgment Dr. Thompson has received grant support from the National Institutes of Health.
Funding Information:
Disclosure Dr. Thompson has received grant support from Astellas and Pfizer.
PY - 2013/4
Y1 - 2013/4
N2 - Fungal diseases of the nose and sinuses encompasses a diverse spectrum of disease. Clinical manifestations are largely dependent upon the immune status of the host, as, given the ubiquitous nature of these organisms, exposure is unavoidable. Asymptomatic colonization of the nasal passages by fungi warrants no treatment and is common, while allergic fungal rhinosinusitis is challenging and often requires a combined approach of surgical intervention, immunotherapy, and corticosteroid administration. A diagnosis requires a combination of IgE immune reactivity, eosinophilic infiltration, and fungi recovery. Similarly, invasive disease may present only after several months of slowly progressive disease, or in rapid and fulminant fashion in the appropriate host. A differentiation of these overlapping syndromes and the pathophysiologic processes at play, and recommended treatment algorithms, are the focus of this review.
AB - Fungal diseases of the nose and sinuses encompasses a diverse spectrum of disease. Clinical manifestations are largely dependent upon the immune status of the host, as, given the ubiquitous nature of these organisms, exposure is unavoidable. Asymptomatic colonization of the nasal passages by fungi warrants no treatment and is common, while allergic fungal rhinosinusitis is challenging and often requires a combined approach of surgical intervention, immunotherapy, and corticosteroid administration. A diagnosis requires a combination of IgE immune reactivity, eosinophilic infiltration, and fungi recovery. Similarly, invasive disease may present only after several months of slowly progressive disease, or in rapid and fulminant fashion in the appropriate host. A differentiation of these overlapping syndromes and the pathophysiologic processes at play, and recommended treatment algorithms, are the focus of this review.
KW - Allergic fungal rhinosinusitis
KW - Eosinophilic fungal rhinosinusitis
KW - Fungal disease
KW - Granulomatous fungal sinusitis
KW - Invasive sinusitis
KW - Overview
KW - Pathophysiology
KW - Treatment
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U2 - 10.1007/s11882-012-0320-1
DO - 10.1007/s11882-012-0320-1
M3 - Review article
C2 - 23135919
AN - SCOPUS:84876331951
VL - 13
SP - 152
EP - 161
JO - Current Allergy and Asthma Reports
JF - Current Allergy and Asthma Reports
SN - 1529-7322
IS - 2
ER -