Fungal disease of the nose and sinuses: An updated overview

Christopher Chang, M. Eric Gershwin, George R. Thompson

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Fungal diseases of the nose and sinuses encompasses a diverse spectrum of disease. Clinical manifestations are largely dependent upon the immune status of the host, as, given the ubiquitous nature of these organisms, exposure is unavoidable. Asymptomatic colonization of the nasal passages by fungi warrants no treatment and is common, while allergic fungal rhinosinusitis is challenging and often requires a combined approach of surgical intervention, immunotherapy, and corticosteroid administration. A diagnosis requires a combination of IgE immune reactivity, eosinophilic infiltration, and fungi recovery. Similarly, invasive disease may present only after several months of slowly progressive disease, or in rapid and fulminant fashion in the appropriate host. A differentiation of these overlapping syndromes and the pathophysiologic processes at play, and recommended treatment algorithms, are the focus of this review.

Original languageEnglish (US)
Pages (from-to)152-161
Number of pages10
JournalCurrent Allergy and Asthma Reports
Issue number2
StatePublished - Apr 2013
Externally publishedYes


  • Allergic fungal rhinosinusitis
  • Eosinophilic fungal rhinosinusitis
  • Fungal disease
  • Granulomatous fungal sinusitis
  • Invasive sinusitis
  • Overview
  • Pathophysiology
  • Treatment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine


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