TY - JOUR
T1 - Fungal disease of the nose and paranasal sinuses
AU - Thompson, George R.
AU - Patterson, Thomas F.
N1 - Funding Information:
Disclosure of potential conflict of interest: G. R. Thompson has received research support from Pfizer . T. F. Patterson has consultant arrangements with Pfizer, Viamet Pharmaceuticals, Toyama, Merck, and Astellas Pharma US and has received research support from Astellas Pharma US, Merck, and Pfizer .
PY - 2012/2
Y1 - 2012/2
N2 - Fungal infections of the nose and paranasal sinuses represent a spectrum of diseases ranging from colonization to invasive rhinosinusitis. Clinical manifestations are largely dependent on the immune status of the host, and given the ubiquitous nature of these organisms, exposure is unavoidable. Noninvasive disease includes asymptomatic fungal colonization, fungus balls, and allergic fungal rhinosinusitis. Invasive disease includes indolent chronic rhinosinusitis, granulomatous fungal sinusitis, and acute fulminant fungal rhinosinusitis. A differentiation of these somewhat overlapping syndromes and the disparate treatment regimens required for effective management are the focus of this review.
AB - Fungal infections of the nose and paranasal sinuses represent a spectrum of diseases ranging from colonization to invasive rhinosinusitis. Clinical manifestations are largely dependent on the immune status of the host, and given the ubiquitous nature of these organisms, exposure is unavoidable. Noninvasive disease includes asymptomatic fungal colonization, fungus balls, and allergic fungal rhinosinusitis. Invasive disease includes indolent chronic rhinosinusitis, granulomatous fungal sinusitis, and acute fulminant fungal rhinosinusitis. A differentiation of these somewhat overlapping syndromes and the disparate treatment regimens required for effective management are the focus of this review.
KW - Fungal colonization
KW - acute fulminant fungal rhinosinusitis
KW - allergic fungal rhinosinusitis
KW - chronic rhinosinusitis
KW - fungus balls
KW - granulomatous fungal sinusitis
UR - http://www.scopus.com/inward/record.url?scp=84856449516&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856449516&partnerID=8YFLogxK
U2 - 10.1016/j.jaci.2011.11.039
DO - 10.1016/j.jaci.2011.11.039
M3 - Article
C2 - 22206776
AN - SCOPUS:84856449516
SN - 0091-6749
VL - 129
SP - 321
EP - 326
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 2
ER -