Fundamental issues related to the origin of melatonin and melatonin isomers during evolution

relation to their biological functions

Dun Xian Tan, Xiaodong Zheng, Jin Kong, Lucien C. Manchester, Ruediger Hardel, Seok Joong Kim, Xiaoying Xu, Russel J Reiter

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Melatonin and melatonin isomers exist and/or coexist in living organisms including yeasts, bacteria and plants. The levels of melatonin isomers are significantly higher than that of melatonin in some plants and in several fermented products such as in wine and bread. Currently, there are no reports documenting the presence of melatonin isomers in vertebrates. From an evolutionary point of view, it is unlikely that melatonin isomers do not exist in vertebrates. On the other hand, large quantities of the microbial flora exist in the gut of the vertebrates. These microorganisms frequently exchange materials with the host. Melatonin isomers, which are produced by these organisms inevitably enter the host’s system. The origins of melatonin and its isomers can be traced back to photosynthetic bacteria and other primitive unicellular organisms. Since some of these bacteria are believed to be the precursors of mitochondria and chloroplasts these cellular organelles may be the primary sites of melatonin production in animals or in plants, respectively. Phylogenic analysis based on its rate-limiting synthetic enzyme, serotonin N-acetyltransferase (SNAT), indicates its multiple origins during evolution. Therefore, it is likely that melatonin and its isomer are also present in the domain of archaea, which perhaps require these molecules to protect them against hostile environments including extremely high or low temperature. Evidence indicates that the initial and primary function of melatonin and its isomers was to serve as the first-line of defence against oxidative stress and all other functions were acquired during evolution either by the process of adoption or by the extension of its antioxidative capacity.

Original languageEnglish (US)
Pages (from-to)15858-15890
Number of pages33
JournalInternational Journal of Molecular Sciences
Volume15
Issue number9
DOIs
StatePublished - Sep 9 2014

Fingerprint

melatonin
Melatonin
Isomers
isomers
vertebrates
organisms
bacteria
Vertebrates
Bacteria
Arylalkylamine N-Acetyltransferase
serotonin
plants (botany)
chloroplasts
wines
organelles
Mitochondria
Oxidative stress
mitochondria
Wine
Bread

Keywords

  • Antioxidant
  • Archaea
  • Chloroplasts
  • Cyanobacteria
  • Evolution
  • Isomer
  • Melatonin
  • Mitochondria
  • Plants

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications

Cite this

Fundamental issues related to the origin of melatonin and melatonin isomers during evolution : relation to their biological functions. / Tan, Dun Xian; Zheng, Xiaodong; Kong, Jin; Manchester, Lucien C.; Hardel, Ruediger; Kim, Seok Joong; Xu, Xiaoying; Reiter, Russel J.

In: International Journal of Molecular Sciences, Vol. 15, No. 9, 09.09.2014, p. 15858-15890.

Research output: Contribution to journalArticle

Tan, Dun Xian ; Zheng, Xiaodong ; Kong, Jin ; Manchester, Lucien C. ; Hardel, Ruediger ; Kim, Seok Joong ; Xu, Xiaoying ; Reiter, Russel J. / Fundamental issues related to the origin of melatonin and melatonin isomers during evolution : relation to their biological functions. In: International Journal of Molecular Sciences. 2014 ; Vol. 15, No. 9. pp. 15858-15890.
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