Functions and regulation of the multitasking FANCM family of DNA motor proteins

Xiaoyu Xue, Patrick Sung, Xiaolan Zhao

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Members of the conserved FANCM family of DNA motor proteins play key roles in genome maintenance processes. FANCM supports genome duplication and repair under different circumstances and also functions in the ATRmediated DNA damage checkpoint. Some of these roles are shared among lower eukaryotic family members. Human FANCM has been linked to Fanconi anemia, a syndrome characterized by cancer predisposition, developmental disorder, and bone marrow failure. Recent studies on human FANCM and its orthologs from other organisms have provided insights into their biological functions, regulation, and collaboration with other genome maintenance factors. This review summarizes the progress made, with the goal of providing an integrated view of the functions and regulation of these enzymes in humans and model organisms and how they advance our understanding of genome maintenance processes.

Original languageEnglish (US)
Pages (from-to)1777-1788
Number of pages12
JournalGenes and Development
Volume29
Issue number17
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

Keywords

  • BLM
  • Crossover control
  • FANCM
  • Fml1
  • MHF
  • Mph1
  • Replication fork regression

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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