Functional similarities of AeEα Ia molecules as determined by analysis with T-cell clones

Barbara N. Beck, Anthony J. Infante, C. Garrison Fathman

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Recognition of AeEα Ia antigens at the functional level was investigated using T-cell clones. The reactivities of an alloreactive and an antigen-reactive clone, both of which recognized AeEα Ia molecules, were compared on a panel of stimulator/antigen-presenting cells of various genotypes. The two clones recognized all tested AebEαxIa molecules, where x is a haplotype capable of expressing an Ia.7-bearing Eα polypeptide. Ia antigen recognition by either clone could be inhibited by the monoclonal antibody Y-17, which recognizes a combinatorial serologic determinant on certain AeEα molecules. There were no differences in the recognition of Ia by the alloreactive versus the antigen-reactive clone, suggesting that Ia antigens are recognized by the two clones in a fundamentally similar way. The recognition of these various Ia molecules by the two cloned T-cell lines provides evidence that the Eα polypeptides from H-2 haplotypes k, d, r, and u are functionally indistinguishable.

Original languageEnglish (US)
Pages (from-to)565-571
Number of pages7
JournalImmunogenetics
Volume15
Issue number6
DOIs
StatePublished - Jun 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Genetics

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