TY - JOUR
T1 - Functional Segregation of the Human Dorsomedial Prefrontal Cortex
AU - Eickhoff, Simon B.
AU - Laird, Angela R.
AU - Fox, Peter T.
AU - Bzdok, Danilo
AU - Hensel, Lukas
N1 - Funding Information:
This study was supported by the Deutsche Forschungsgemeinschaft (DFG, EI 816/4-1 to S.B.E. and L.A. 3071/3-1 to S.B.E.; EI 816/6-1 to S.B.E. and D.B.), the National Institute of Mental Health (R01-MH074457 to A.R.L., P.T.F., and S.B.E.), the Helmholtz Initiative on Systems Biology (Human Brain Model to S.B.E.), and the German National Academic Foundation (D.B.).
Publisher Copyright:
© The Author 2014. Published by Oxford University Press. All rights reserved.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - The human dorsomedial prefrontal cortex (dmPFC) has been implicated in various complex cognitive processes, including social cognition. To unravel its functional organization, we assessed the dmPFC's regional heterogeneity, connectivity patterns, and functional profiles. First, the heterogeneity of a dmPFC seed, engaged during social processing, was investigated by assessing local differences in whole-brain coactivation profiles. Second, functional connectivity of the ensuing dmPFC clusters was compared by task-constrained meta-analytic coactivation mapping and task-unconstrained resting-state correlations. Third, dmPFC clusters were functionally profiled by forward/reverse inference. The dmPFC seed was thus segregated into 4 clusters (rostroventral, rostrodorsal, caudal-right, and caudal-left). Both rostral clusters were connected to the amygdala and hippocampus and associated with memory and social cognitive tasks in functional decoding. The rostroventral cluster exhibited strongest connectivity to the default mode network. Unlike the rostral segregation, the caudal dmPFC was divided by hemispheres. The caudal-right cluster was strongly connected to a frontoparietal network (dorsal attention network), whereas the caudal-left cluster was strongly connected to the anterior midcingulate cortex and bilateral anterior insula (salience network). In conclusion, we demonstrate that a dmPFC seed reflecting social processing can be divided into 4 separate functional modules that contribute to distinct facets of advanced human cognition.
AB - The human dorsomedial prefrontal cortex (dmPFC) has been implicated in various complex cognitive processes, including social cognition. To unravel its functional organization, we assessed the dmPFC's regional heterogeneity, connectivity patterns, and functional profiles. First, the heterogeneity of a dmPFC seed, engaged during social processing, was investigated by assessing local differences in whole-brain coactivation profiles. Second, functional connectivity of the ensuing dmPFC clusters was compared by task-constrained meta-analytic coactivation mapping and task-unconstrained resting-state correlations. Third, dmPFC clusters were functionally profiled by forward/reverse inference. The dmPFC seed was thus segregated into 4 clusters (rostroventral, rostrodorsal, caudal-right, and caudal-left). Both rostral clusters were connected to the amygdala and hippocampus and associated with memory and social cognitive tasks in functional decoding. The rostroventral cluster exhibited strongest connectivity to the default mode network. Unlike the rostral segregation, the caudal dmPFC was divided by hemispheres. The caudal-right cluster was strongly connected to a frontoparietal network (dorsal attention network), whereas the caudal-left cluster was strongly connected to the anterior midcingulate cortex and bilateral anterior insula (salience network). In conclusion, we demonstrate that a dmPFC seed reflecting social processing can be divided into 4 separate functional modules that contribute to distinct facets of advanced human cognition.
KW - connectivity-based parcellation
KW - default mode network
KW - functional connectivity
KW - lateralization
KW - social cognition
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U2 - 10.1093/cercor/bhu250
DO - 10.1093/cercor/bhu250
M3 - Article
C2 - 25331597
AN - SCOPUS:84959897151
SN - 1047-3211
VL - 26
SP - 304
EP - 321
JO - Cerebral Cortex
JF - Cerebral Cortex
IS - 1
ER -