Functional role of AMP-activated protein kinase in the heart during exercise

Nicolas Musi, Michael F. Hirshman, Michael Arad, Yanqiu Xing, Nobuharu Fujii, Jason Pomerleau, Ferhaan Ahmad, Charles I. Berul, Jon G. Seidman, Rong Tian, Laurie J. Goodyear

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

AMP-activated protein kinase (AMPK) plays a critical role in maintaining energy homeostasis and cardiac function during ischemia in the heart. However, the functional role of AMPK in the heart during exercise is unknown. We examined whether acute exercise increases AMPK activity in mouse hearts and determined the significance of these increases by studying transgenic (TG) mice expressing a cardiac-specific dominant-negative (inactivating) AMPKα2 subunit. Exercise increased cardiac AMPKα2 activity in the wild type mice but not in TG. We found that inactivation of AMPK did not result in abnormal ATP and glycogen consumption during exercise, cardiac function assessed by heart rhythm telemetry and stress echocardiography, or in maximal exercise capacity.

Original languageEnglish (US)
Pages (from-to)2045-2050
Number of pages6
JournalFEBS Letters
Volume579
Issue number10
DOIs
StatePublished - Apr 11 2005
Externally publishedYes

Keywords

  • AMP-activated protein kinase
  • Acetyl CoA carboxylase
  • Exercise
  • Heart
  • p38

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Musi, N., Hirshman, M. F., Arad, M., Xing, Y., Fujii, N., Pomerleau, J., Ahmad, F., Berul, C. I., Seidman, J. G., Tian, R., & Goodyear, L. J. (2005). Functional role of AMP-activated protein kinase in the heart during exercise. FEBS Letters, 579(10), 2045-2050. https://doi.org/10.1016/j.febslet.2005.02.052