Functional organization of the fusiform gyrus revealed with connectivity profiles

Wen Zhang, Jiaojian Wang, Lingzhong Fan, Yuanchao Zhang, Peter T Fox, Simon B. Eickhoff, Chunshui Yu, Tianzi Jiang

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Within the object recognition-related ventral visual stream, the human fusiform gyrus (FG), which topographically connects the striate cortex to the inferior temporal lobe, plays a pivotal role in high-level visual/cognitive functions. However, though there are many previous investigations of distinct functional modules within the FG, the functional organization of the whole FG in its full functional heterogeneity has not yet been established. In the current study, a replicable functional organization of the FG based on distinct anatomical connectivity patterns was identified. The FG was parcellated into medial (FGm), lateral (FGl), and anterior (FGa) regions using diffusion tensor imaging. We validated the reasonability of such an organizational scheme from the perspective of resting-state whole brain functional connectivity patterns and the involvement of functional subnetworks. We found corroborating support for these three distinct modules, and suggest that the FGm serves as a transition region that combines multiple stimuli, the FGl is responsible for categorical recognition, and the FGa is involved in semantic understanding. These findings support two organizational functional transitions of the ventral temporal gyrus, a posterior/anterior direction of visual/semantic processing, and a media/lateral direction of high-level visual processing. Our results may facilitate a more detailed study of the human FG in the future. Hum Brain Mapp 37:3003–3016, 2016.

Original languageEnglish (US)
Pages (from-to)3003-3016
Number of pages14
JournalHuman Brain Mapping
Volume37
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

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Keywords

  • functional characterization
  • fusiform gyrus
  • parcellation
  • resting-state
  • tractography

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Zhang, W., Wang, J., Fan, L., Zhang, Y., Fox, P. T., Eickhoff, S. B., ... Jiang, T. (2016). Functional organization of the fusiform gyrus revealed with connectivity profiles. Human Brain Mapping, 37(8), 3003-3016. https://doi.org/10.1002/hbm.23222