Functional neuroimaging of the baboon during concurrent image-guided transcranial magnetic stimulation

Felipe S. Salinas, C. Ákos Szabó, Wei Zhang, Lisa Jones, M. Michelle Leland, Hsiao Ying Wey, Timothy Q. Duong, Peter T. Fox, Shalini Narayana

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Transcranial magnetic stimulation (TMS) has well-established applications in basic neuroscience and promising applications in neurological and psychiatric disorders. However the underlying mechanisms of TMS-induced alterations in brain function are not well understood. As a result, treatment design parameters are determined ad hoc and not informed by any coherent theory or model. Once the mechanisms underlying TMS's modulatory effects on brain systems are better understood and modeled, TMS's potential as a therapeutic and/or investigative tool will be more readily explored and exploited. An animal model is better suited to study different TMS variables, therefore we developed a baboon model to facilitate testing of some of the current theoretical models of TMS interactions with brain regions. We have demonstrated the feasibility of this approach by successfully imaging cerebral blood flow (CBF) changes with H 2 15O positron emission tomography imaging during high-frequency, suprathreshold repetitive TMS in the primary motor cortex of five healthy, adult baboons.

Original languageEnglish (US)
Pages (from-to)1393-1401
Number of pages9
JournalNeuroImage
Volume57
Issue number4
DOIs
StatePublished - Aug 15 2011

Keywords

  • Animal models
  • FMRI
  • Motor cortex
  • PET
  • TMS

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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