Functional lipidomics: The roles of specialized lipids and lipid-protein interactions in modulating neuronal function

Richard W. Gross, Christopher M. Jenkins, Jingyue Yang, David J. Mancuso, Xianlin Han

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Lipids fulfill multiple specialized roles in neuronal function. In brain, the conduction of electrical impulses, synaptic function, and complex signaling pathways depend on the temporally and spatially coordinated interactions of specialized lipids (e.g., arachidonic acid and plasmalogens), proteins (e.g., ion channels, phospholipases and cyclooxygenases) and integrative lipid-protein interactions. Recent technical advances in mass spectrometry have allowed unparalled insight into the roles of lipids in neuronal function. Through shotgun lipidomics and multidimensional mass spectrometry, in conjunction with the identification of new classes of phospholipases (e.g., calcium dependent and calcium independent intracellular phospholipases), new roles for lipids in cerebral function have been accrued. This review summarizes the advances in our understanding of the types of lipids and phospholipases in the brain and the role of functional lipidomics in increasing our chemical understanding of complex neuronal processes.

Original languageEnglish (US)
Pages (from-to)52-64
Number of pages13
JournalProstaglandins and Other Lipid Mediators
Volume77
Issue number1-4 SPEC. ISS.
DOIs
StatePublished - Sep 2005
Externally publishedYes

Keywords

  • Brain
  • Calmodulin
  • Ion channels
  • Lipidomics
  • Lysolipids
  • Phospholipase
  • Plasmalogens

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

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