Functional integrity in children with anoxic brain injury from drowning

Mariam Ishaque, Janessa H. Manning, Mary D. Woolsey, Crystal G. Franklin, Elizabeth W. Tullis, Christian F. Beckmann, Peter T. Fox

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Drowning is a leading cause of accidental injury and death in young children. Anoxic brain injury (ABI) is a common consequence of drowning and can cause severe neurological morbidity in survivors. Assessment of functional status and prognostication in drowning victims can be extremely challenging, both acutely and chronically. Structural neuroimaging modalities (CT and MRI) have been of limited clinical value. Here, we tested the utility of resting-state functional MRI (rs-fMRI) for assessing brain functional integrity in this population. Eleven children with chronic, spastic quadriplegia due to drowning-induced ABI were investigated. All were comatose immediately after the injury and gradually regained consciousness, but with varying ability to communicate their cognitive state. Eleven neurotypical children matched for age and gender formed the control group. Resting-state fMRI and co-registered T1-weighted anatomical MRI were acquired at night during drug-aided sleep. Network integrity was quantified by independent components analysis (ICA), at both group- and per-subject levels. Functional-status assessments based on in-home observations were provided by families and caregivers. Motor ICNs were grossly compromised in ABI patients both group-wise and individually, concordant with their prominent motor deficits. Striking preservations of perceptual and cognitive ICNs were observed, and the degree of network preservation correlated (ρ = 0.74) with the per-subject functional status assessments. Collectively, our findings indicate that rs-fMRI has promise for assessing brain functional integrity in ABI and, potentially, in other disorders. Furthermore, our observations suggest that the severe motor deficits observed in this population can mask relatively intact perceptual and cognitive capabilities. Hum Brain Mapp 38:4813–4831, 2017.

Original languageEnglish (US)
Pages (from-to)4813-4831
Number of pages19
JournalHuman Brain Mapping
Volume38
Issue number10
DOIs
StatePublished - Oct 2017

Keywords

  • anoxic brain injury
  • fMRI
  • functional magnetic resonance imaging
  • hypoxic–ischemic encephalopathy
  • independent components analysis
  • locked-in syndrome
  • minimally conscious state
  • neural networks
  • resting state
  • rs-fMRI
  • rs-fcMRI

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Functional integrity in children with anoxic brain injury from drowning'. Together they form a unique fingerprint.

Cite this