Functional evaluation and analysis of predicted miRNA-mRNA regulatory network

Saleh Tamim, Jianhua Ruan

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    MicroRNAs (miRNAs) are known to play important roles in the way their target genes behave. By causing translational repression or degradation of their targets, miRNAs affect many biological functions and in turn are linked to many diseases. One way of understanding the functions of miRNAs is by identifying and analyzing their target genes through lab experiments. However, due to the inefficiency of this method, alternative ways had to be explored, one of which is the use of computational and bioinformatics approaches. Even though these approaches can save a lot of experimental time and chemical cost, their results can be questionable. In this study, we evaluated three commonly used target prediction tools by analyzing their predicted targets through miRNA-mRNA network. Our approach combines the use of gene function similarity and gene expression data in determining the most probable true targets. Our results show wide outspread of predicted targets with less overlap among the tools. Overall, TargetScan seems to perform better compared to the other two.

    Original languageEnglish (US)
    Title of host publicationProceeding of the 2012 ACM Research in Applied Computation Symposium, RACS 2012
    Pages70-71
    Number of pages2
    DOIs
    StatePublished - Dec 1 2012
    Event2012 ACM Research in Applied Computation Symposium, RACS 2012 - San Antonio, TX, United States
    Duration: Oct 23 2012Oct 26 2012

    Publication series

    NameProceeding of the 2012 ACM Research in Applied Computation Symposium, RACS 2012

    Conference

    Conference2012 ACM Research in Applied Computation Symposium, RACS 2012
    Country/TerritoryUnited States
    CitySan Antonio, TX
    Period10/23/1210/26/12

    Keywords

    • Computational
    • miRNA
    • mRNA
    • Prediction
    • Tools

    ASJC Scopus subject areas

    • Computational Theory and Mathematics

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