TY - JOUR
T1 - Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR.
AU - Vadlamudi, Ratna K.
AU - Kumar, Rakesh
PY - 2007
Y1 - 2007
N2 - Proline-, glutamic acid-, and leucine-rich protein (PELP)1, also known as modulator of nongenomic actions of the estrogen receptor (MNAR), is a novel nuclear receptor coregulator with a multitude of functions. PELP1/MNAR serves as a scaffolding protein that couples various signaling complexes with nuclear receptors and participates in genomic and nongenomic functions. Recent data suggest that PELP1/MNAR expression is deregulated in several cancers, including breast, endometrial, prostate, and ovarian cancer, and that PELP1/MNAR interacts with several oncogenes. In this review, we summarize the emerging biological properties and functions of PELP1/MNAR.
AB - Proline-, glutamic acid-, and leucine-rich protein (PELP)1, also known as modulator of nongenomic actions of the estrogen receptor (MNAR), is a novel nuclear receptor coregulator with a multitude of functions. PELP1/MNAR serves as a scaffolding protein that couples various signaling complexes with nuclear receptors and participates in genomic and nongenomic functions. Recent data suggest that PELP1/MNAR expression is deregulated in several cancers, including breast, endometrial, prostate, and ovarian cancer, and that PELP1/MNAR interacts with several oncogenes. In this review, we summarize the emerging biological properties and functions of PELP1/MNAR.
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U2 - 10.1621/nrs.05004
DO - 10.1621/nrs.05004
M3 - Review article
C2 - 17525794
AN - SCOPUS:34250619620
SN - 1550-7629
VL - 5
SP - e004
JO - Nuclear receptor signaling
JF - Nuclear receptor signaling
ER -