Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR.

Ratna K. Vadlamudi, Rakesh Kumar

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations

Abstract

Proline-, glutamic acid-, and leucine-rich protein (PELP)1, also known as modulator of nongenomic actions of the estrogen receptor (MNAR), is a novel nuclear receptor coregulator with a multitude of functions. PELP1/MNAR serves as a scaffolding protein that couples various signaling complexes with nuclear receptors and participates in genomic and nongenomic functions. Recent data suggest that PELP1/MNAR expression is deregulated in several cancers, including breast, endometrial, prostate, and ovarian cancer, and that PELP1/MNAR interacts with several oncogenes. In this review, we summarize the emerging biological properties and functions of PELP1/MNAR.

Original languageEnglish (US)
Pages (from-to)e004
JournalNuclear receptor signaling
Volume5
DOIs
StatePublished - 2007

ASJC Scopus subject areas

  • Medicine(all)

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