FSH Stimulation of cAMP Accumulation in Hamster Sertoli Cells: Effect of Age and Optic Enucleation

JERROLD J. HEINDEL, ALBERT S. BERKOWITZ, RON PHILO, JAMES P. PRESLOCK

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22 Scopus citations

Abstract

Sertoli cells isolated from immature, adult, and adult optic‐enucleated hamsters respond to FSH, but not to LH, with an increase in cAMP accumulation. There is an age‐related decline in responsiveness of Sertoli cells to FSH. Sertoli cells cultured from optic‐enucleated adult hamsters with regressed testes respond to FSH with an Increased accumulation of cAMP similar in magnitude to that of immature Sertoli cells. These data indicate that optic enucleatlon results in a reversal of the sensitivity of Sertoll cells to FSH, an effect which may be important for the reinitiation of spermatogenesis, which naturally follows the regressed state. 1981 American Society of Andrology

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalJournal of Andrology
Volume2
Issue number4
DOIs
StatePublished - 1981

Keywords

  • Sertoli cells
  • cAMP
  • hamsters
  • optic enucleation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Urology

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