Abstract
Sertoli cells isolated from immature, adult, and adult optic‐enucleated hamsters respond to FSH, but not to LH, with an increase in cAMP accumulation. There is an age‐related decline in responsiveness of Sertoli cells to FSH. Sertoli cells cultured from optic‐enucleated adult hamsters with regressed testes respond to FSH with an Increased accumulation of cAMP similar in magnitude to that of immature Sertoli cells. These data indicate that optic enucleatlon results in a reversal of the sensitivity of Sertoll cells to FSH, an effect which may be important for the reinitiation of spermatogenesis, which naturally follows the regressed state. 1981 American Society of Andrology
Original language | English (US) |
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Pages (from-to) | 217-221 |
Number of pages | 5 |
Journal | Journal of Andrology |
Volume | 2 |
Issue number | 4 |
DOIs | |
State | Published - 1981 |
Externally published | Yes |
Keywords
- Sertoli cells
- cAMP
- hamsters
- optic enucleation
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Reproductive Medicine
- Endocrinology
- Urology