TY - JOUR
T1 - Fronto-limbic circuitry in euthymic bipolar disorder
T2 - Evidence for prefrontal hyperactivation
AU - Robinson, Jennifer L.
AU - Monkul, E. Serap
AU - Tordesillas-Gutiérrez, Diana
AU - Franklin, Crystal
AU - Bearden, Carrie E.
AU - Fox, Peter T.
AU - Glahn, David C.
N1 - Funding Information:
This research was supported by grants from NARSAD and the GCRC Imaging Core.
PY - 2008/11/30
Y1 - 2008/11/30
N2 - Functional magnetic resonance imaging (fMRI) studies of bipolar disorder have revealed fronto-limbic abnormalities in patients during manic and depressive episodes. However, relatively few studies have examined neural activity during euthymia, leaving unanswered questions concerning the impact of mood state on activity in these brain regions. In the present study, we examined 15 remitted bipolar type I patients and 16 demographically matched healthy comparison subjects during performance on an affective face-matching task previously shown to elicit amygdala hyperactivation and prefrontal hypoactivation in manic relative to healthy subjects. In our euthymic sample, amygdala activation did not differ from controls. However, bipolar patients showed hyperactivation in inferior prefrontal cortical regions compared with controls, a finding that contrasts with the hypoactivation previously reported in this region in manic patients. Given the reciprocal relationship between the prefrontal cortex and limbic structures, we propose state-related amygdala activity, similar to that of healthy controls, may be associated with prefrontal hyperactivation when bipolar patients are asymptomatic.
AB - Functional magnetic resonance imaging (fMRI) studies of bipolar disorder have revealed fronto-limbic abnormalities in patients during manic and depressive episodes. However, relatively few studies have examined neural activity during euthymia, leaving unanswered questions concerning the impact of mood state on activity in these brain regions. In the present study, we examined 15 remitted bipolar type I patients and 16 demographically matched healthy comparison subjects during performance on an affective face-matching task previously shown to elicit amygdala hyperactivation and prefrontal hypoactivation in manic relative to healthy subjects. In our euthymic sample, amygdala activation did not differ from controls. However, bipolar patients showed hyperactivation in inferior prefrontal cortical regions compared with controls, a finding that contrasts with the hypoactivation previously reported in this region in manic patients. Given the reciprocal relationship between the prefrontal cortex and limbic structures, we propose state-related amygdala activity, similar to that of healthy controls, may be associated with prefrontal hyperactivation when bipolar patients are asymptomatic.
KW - Amygdala
KW - Emotional processing
KW - Euthymia
KW - Functional magnetic resonance imaging
KW - Prefrontal cortex
KW - fMRI
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U2 - 10.1016/j.pscychresns.2007.12.004
DO - 10.1016/j.pscychresns.2007.12.004
M3 - Article
C2 - 18930635
AN - SCOPUS:55049090490
SN - 0925-4927
VL - 164
SP - 106
EP - 113
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 2
ER -