Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy

Anand Kumar, Albert Thomas, Helen Lavretsky, Kenneth Yue, Amir Huda, John Curran, Talaignair Venkatraman, Laverne Estanol, Jim Mintz, Michael Mega, Arthur Toga

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Objective: Neuroanatomical abnormalities have been identified in patients with late-life mood disorders by using magnetic resonance imaging. This study examined the biochemical correlates of late-life major depression in the frontal gray and white matter by using single-voxel proton spectroscopy. Method: Twenty elderly patients with major depression and 18 comparison subjects similar in age and gender to the patients were scanned on a 1.5-T magnetic resonance scanner with head coil. Voxels were placed in the left dorsolateral white matter and bilaterally in the anterior cingulate gray matter. Absolute levels of N-acetylaspartate, choline, myo-inositol, and creatine were estimated with the LC-Model algorithm. Ratios of metabolite to creatine levels were computed from the absolute values. Results: myo-Inositol/creatine and choline/creatine ratios were significantly higher in the frontal white matter in the major depression group than in the comparison group. The groups had no significant differences in the metabolite ratios in the gray matter. Conclusions: Biochemical changes in the white matter may provide some of the neurobiological substrates to late-life major depression.

Original languageEnglish (US)
Pages (from-to)630-636
Number of pages7
JournalAmerican Journal of Psychiatry
Volume159
Issue number4
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Creatine
Depression
Inositol
Choline
Gyrus Cinguli
Mood Disorders
Protons
Spectrum Analysis
Magnetic Resonance Spectroscopy
Head
Magnetic Resonance Imaging
Proton Magnetic Resonance Spectroscopy
White Matter
Gray Matter

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy. / Kumar, Anand; Thomas, Albert; Lavretsky, Helen; Yue, Kenneth; Huda, Amir; Curran, John; Venkatraman, Talaignair; Estanol, Laverne; Mintz, Jim; Mega, Michael; Toga, Arthur.

In: American Journal of Psychiatry, Vol. 159, No. 4, 2002, p. 630-636.

Research output: Contribution to journalArticle

Kumar, A, Thomas, A, Lavretsky, H, Yue, K, Huda, A, Curran, J, Venkatraman, T, Estanol, L, Mintz, J, Mega, M & Toga, A 2002, 'Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy', American Journal of Psychiatry, vol. 159, no. 4, pp. 630-636. https://doi.org/10.1176/appi.ajp.159.4.630
Kumar, Anand ; Thomas, Albert ; Lavretsky, Helen ; Yue, Kenneth ; Huda, Amir ; Curran, John ; Venkatraman, Talaignair ; Estanol, Laverne ; Mintz, Jim ; Mega, Michael ; Toga, Arthur. / Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy. In: American Journal of Psychiatry. 2002 ; Vol. 159, No. 4. pp. 630-636.
@article{77aae05f189c452c81c9471a4c947d3c,
title = "Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy",
abstract = "Objective: Neuroanatomical abnormalities have been identified in patients with late-life mood disorders by using magnetic resonance imaging. This study examined the biochemical correlates of late-life major depression in the frontal gray and white matter by using single-voxel proton spectroscopy. Method: Twenty elderly patients with major depression and 18 comparison subjects similar in age and gender to the patients were scanned on a 1.5-T magnetic resonance scanner with head coil. Voxels were placed in the left dorsolateral white matter and bilaterally in the anterior cingulate gray matter. Absolute levels of N-acetylaspartate, choline, myo-inositol, and creatine were estimated with the LC-Model algorithm. Ratios of metabolite to creatine levels were computed from the absolute values. Results: myo-Inositol/creatine and choline/creatine ratios were significantly higher in the frontal white matter in the major depression group than in the comparison group. The groups had no significant differences in the metabolite ratios in the gray matter. Conclusions: Biochemical changes in the white matter may provide some of the neurobiological substrates to late-life major depression.",
author = "Anand Kumar and Albert Thomas and Helen Lavretsky and Kenneth Yue and Amir Huda and John Curran and Talaignair Venkatraman and Laverne Estanol and Jim Mintz and Michael Mega and Arthur Toga",
year = "2002",
doi = "10.1176/appi.ajp.159.4.630",
language = "English (US)",
volume = "159",
pages = "630--636",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "4",

}

TY - JOUR

T1 - Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy

AU - Kumar, Anand

AU - Thomas, Albert

AU - Lavretsky, Helen

AU - Yue, Kenneth

AU - Huda, Amir

AU - Curran, John

AU - Venkatraman, Talaignair

AU - Estanol, Laverne

AU - Mintz, Jim

AU - Mega, Michael

AU - Toga, Arthur

PY - 2002

Y1 - 2002

N2 - Objective: Neuroanatomical abnormalities have been identified in patients with late-life mood disorders by using magnetic resonance imaging. This study examined the biochemical correlates of late-life major depression in the frontal gray and white matter by using single-voxel proton spectroscopy. Method: Twenty elderly patients with major depression and 18 comparison subjects similar in age and gender to the patients were scanned on a 1.5-T magnetic resonance scanner with head coil. Voxels were placed in the left dorsolateral white matter and bilaterally in the anterior cingulate gray matter. Absolute levels of N-acetylaspartate, choline, myo-inositol, and creatine were estimated with the LC-Model algorithm. Ratios of metabolite to creatine levels were computed from the absolute values. Results: myo-Inositol/creatine and choline/creatine ratios were significantly higher in the frontal white matter in the major depression group than in the comparison group. The groups had no significant differences in the metabolite ratios in the gray matter. Conclusions: Biochemical changes in the white matter may provide some of the neurobiological substrates to late-life major depression.

AB - Objective: Neuroanatomical abnormalities have been identified in patients with late-life mood disorders by using magnetic resonance imaging. This study examined the biochemical correlates of late-life major depression in the frontal gray and white matter by using single-voxel proton spectroscopy. Method: Twenty elderly patients with major depression and 18 comparison subjects similar in age and gender to the patients were scanned on a 1.5-T magnetic resonance scanner with head coil. Voxels were placed in the left dorsolateral white matter and bilaterally in the anterior cingulate gray matter. Absolute levels of N-acetylaspartate, choline, myo-inositol, and creatine were estimated with the LC-Model algorithm. Ratios of metabolite to creatine levels were computed from the absolute values. Results: myo-Inositol/creatine and choline/creatine ratios were significantly higher in the frontal white matter in the major depression group than in the comparison group. The groups had no significant differences in the metabolite ratios in the gray matter. Conclusions: Biochemical changes in the white matter may provide some of the neurobiological substrates to late-life major depression.

UR - http://www.scopus.com/inward/record.url?scp=0036218889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036218889&partnerID=8YFLogxK

U2 - 10.1176/appi.ajp.159.4.630

DO - 10.1176/appi.ajp.159.4.630

M3 - Article

C2 - 11925302

AN - SCOPUS:0036218889

VL - 159

SP - 630

EP - 636

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 4

ER -