Frequent Transmission of HTLV-III Among Spouses of Patients With AIDS-Related Complex and AIDS

Robert R. Redfield, Phillip D. Markham, Syed Zaki Salahuddin, M. G. Sarngadharan, Anne J. Bodner, Thomas M. Folks, William R. Ballou, D. Craig Wright, Robert C. Gallo

Research output: Contribution to journalArticle

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Abstract

Seven cases of acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) associated with human T-cell leukemia (lymphotropic) virus (HTLV)-III infection were documented in married males whose family members consented to medical evaluation. Five spouses also had evidence of HTLV-III infection documented by isolation of virus and by detection of serum antibody directed against viral structural proteins. Three of the five HTLV-positive spouses also had clinical evidence of ARC. The remaining four spouses were clinically healthy. Eleven children (between 14 months and 13 years of age) were also evaluated for evidence of disease and exposure to HTLV-III. Only one 14-month-old child was seropositive for antibody to HTLV-III. These data support the opinion that close household contact to patients with ARC or AIDS is not an efficient mechanism for virus transmission, while demonstrating that HTLV-III can be transmitted by repeated heterosexual contact.

Original languageEnglish (US)
Pages (from-to)1571-1573
Number of pages3
JournalJAMA - Journal of the American Medical Association
Volume253
Issue number11
DOIs
StatePublished - Mar 15 1985
Externally publishedYes

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Spouses
AIDS-Related Complex
Acquired Immunodeficiency Syndrome
HIV
HIV Infections
Viruses
Deltaretrovirus
Viral Structural Proteins
HIV Antibodies
Heterosexuality
Antibodies
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Redfield, R. R., Markham, P. D., Salahuddin, S. Z., Sarngadharan, M. G., Bodner, A. J., Folks, T. M., ... Gallo, R. C. (1985). Frequent Transmission of HTLV-III Among Spouses of Patients With AIDS-Related Complex and AIDS. JAMA - Journal of the American Medical Association, 253(11), 1571-1573. https://doi.org/10.1001/jama.1985.03350350065021

Frequent Transmission of HTLV-III Among Spouses of Patients With AIDS-Related Complex and AIDS. / Redfield, Robert R.; Markham, Phillip D.; Salahuddin, Syed Zaki; Sarngadharan, M. G.; Bodner, Anne J.; Folks, Thomas M.; Ballou, William R.; Wright, D. Craig; Gallo, Robert C.

In: JAMA - Journal of the American Medical Association, Vol. 253, No. 11, 15.03.1985, p. 1571-1573.

Research output: Contribution to journalArticle

Redfield, RR, Markham, PD, Salahuddin, SZ, Sarngadharan, MG, Bodner, AJ, Folks, TM, Ballou, WR, Wright, DC & Gallo, RC 1985, 'Frequent Transmission of HTLV-III Among Spouses of Patients With AIDS-Related Complex and AIDS', JAMA - Journal of the American Medical Association, vol. 253, no. 11, pp. 1571-1573. https://doi.org/10.1001/jama.1985.03350350065021
Redfield, Robert R. ; Markham, Phillip D. ; Salahuddin, Syed Zaki ; Sarngadharan, M. G. ; Bodner, Anne J. ; Folks, Thomas M. ; Ballou, William R. ; Wright, D. Craig ; Gallo, Robert C. / Frequent Transmission of HTLV-III Among Spouses of Patients With AIDS-Related Complex and AIDS. In: JAMA - Journal of the American Medical Association. 1985 ; Vol. 253, No. 11. pp. 1571-1573.
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