TY - JOUR
T1 - Free T4, free T3, and reverse T3in critically III, thermally injured patients
AU - Becker, Richard A.
AU - Wilmore, Douglas W.
AU - Goodwin, Cleon W.
AU - Zitzka, Laudia A.
AU - Wartofsky, Leonard
AU - Burman, Kenneth D.
AU - Mason, Arthur D.
AU - Pruitt, Basil A.
PY - 1980/9
Y1 - 1980/9
N2 - A prospective study of thyroid function was performed in 25 thermally injured patients. These patients are divided into two groups. The first group contains five patients with greater than 50% burn size studied longitudinally during the first 15 days following thermal injury. Significant suppression of serum concentrations of 3,5,3'-triiodothyronine (T3) and elevation of serum concentrations of 3,3',5'-triiodothyronine (rT3) were seen. The free thyroxine index and serum TSH concentrations remained within the normal range. To assess the clinical significance of these alterations in peripheral thyroid hormone concentrations, a second group of 20 patients was studied. We measured the free serum levels of T4(FT4) and T3(FT3) in ten patients, mean age 34 years, mean burn size 56%, studied during a period of clinical deterioration, and in ten patients of comparable age and burn size who were clinically stable. Both FT4 and T3values were significantly lower in the unstable patients (p < 0.01). All FT3values for the unstable patients (M ± SE), 193 ± 14 pg/dl, were below the normal range for FT3of 230 to 669 pg/dl, and significantly lower than those observed in the stable patients (M ± SE), 430 ± 59 pg/dl (p < 0.001). This correlation of biochemical hypothyroidism with clinical deterioration may have functional significance for the critically ill trauma patient.
AB - A prospective study of thyroid function was performed in 25 thermally injured patients. These patients are divided into two groups. The first group contains five patients with greater than 50% burn size studied longitudinally during the first 15 days following thermal injury. Significant suppression of serum concentrations of 3,5,3'-triiodothyronine (T3) and elevation of serum concentrations of 3,3',5'-triiodothyronine (rT3) were seen. The free thyroxine index and serum TSH concentrations remained within the normal range. To assess the clinical significance of these alterations in peripheral thyroid hormone concentrations, a second group of 20 patients was studied. We measured the free serum levels of T4(FT4) and T3(FT3) in ten patients, mean age 34 years, mean burn size 56%, studied during a period of clinical deterioration, and in ten patients of comparable age and burn size who were clinically stable. Both FT4 and T3values were significantly lower in the unstable patients (p < 0.01). All FT3values for the unstable patients (M ± SE), 193 ± 14 pg/dl, were below the normal range for FT3of 230 to 669 pg/dl, and significantly lower than those observed in the stable patients (M ± SE), 430 ± 59 pg/dl (p < 0.001). This correlation of biochemical hypothyroidism with clinical deterioration may have functional significance for the critically ill trauma patient.
UR - http://www.scopus.com/inward/record.url?scp=0018910499&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018910499&partnerID=8YFLogxK
U2 - 10.1097/00005373-198009000-00001
DO - 10.1097/00005373-198009000-00001
M3 - Article
C2 - 7411659
AN - SCOPUS:0018910499
VL - 20
SP - 713
EP - 721
JO - Journal of Trauma and Acute Care Surgery
JF - Journal of Trauma and Acute Care Surgery
SN - 2163-0755
IS - 9
ER -