TY - JOUR
T1 - Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men
T2 - The framingham offspring study
AU - Krasnoff, Joanne B.
AU - Basaria, Shehzad
AU - Pencina, Michael J.
AU - Jasuja, Guneet K.
AU - Vasan, Ramachandran S.
AU - Ulloor, Jagadish
AU - Zhang, Anqi
AU - Coviello, Andrea
AU - Kelly-Hayes, Margaret
AU - D'Agostino, Ralph B.
AU - Wolf, Philip A.
AU - Bhasin, Shalender
AU - Murabito, Joanne M.
N1 - Funding Information:
Disclosure Summary: S.B. received research support from the Centers for Disease Control Foundation.
Funding Information:
This work was supported by National Institute on Aging , 1RO1AG31206 ; Boston Claude D. Pepper Older Americans Independence Center , 5P30 AG31679 ; and NIH grants AG029451-01A2 and 2R01 AG16495 . The Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health and Boston University School of Medicine was supported by the National Heart, Lung, and Blood Institute's Framingham Heart Study contract No. N01-HC-25195 .
PY - 2010/6
Y1 - 2010/6
N2 - Context: Mobility limitation is associated with increased morbidity and mortality. The relationship between circulating testosterone and mobility limitation and physical performance is incompletely understood. Objective: Our objective was to examine cross-sectional and prospective relations between baseline sex hormones and mobility limitations and physical performance in community-dwelling older men. Design, Setting, and Participants: We conducted cross-sectional and longitudinal analyses of 1445 men (mean age 61.0 ± 9.5 yr) who attended Framingham Offspring Study examinations 7 and 8 (mean 6.6 yr apart). Total testosterone (TT) was measured by liquid chromatography tandem mass spectrometry at examination 7. Cross-sectionalandlongitudinal analyses of mobility limitationand physical performance were performed with continuous (per SD) and dichotomized [low TT and free testosterone (FT) and high SHBG vs. normal] hormone levels. Main Outcome Measures: Self-reported mobility limitation, subjective health, usual walking speed,andgrip strengthwereassessed at examinations 7and8. Short physical performance battery was performed at examination 7. Results: Higher continuous FT was positively associated with short physical performance battery score (β = 0.13; P = 0.008), usual walking speed (β = 0.02; P = 0.048), and lower risk of poor subjective health [odds ratio (OR) = 0.72; P = 0.01]. In prospective analysis, 1 SD increase in baseline FT was associated with lower risk of developing mobility limitation (OR = 0.78; 95% confidence interval = 0.62-0.97) and progression of mobility limitation (OR = 0.75;95%confidence interval = 0.60-0.93). Men with low baseline FT had 57% higher odds of reporting incident mobility limitation (P = 0.03) and 68% higher odds of worsening of mobility limitation (P = 0.007). Conclusions: Lower levels of baseline FT are associated with a greater risk of incident or worsening mobility limitation in community-dwelling older men. Whether this risk can be reduced with testosterone therapy needs to be determined by randomized trials.
AB - Context: Mobility limitation is associated with increased morbidity and mortality. The relationship between circulating testosterone and mobility limitation and physical performance is incompletely understood. Objective: Our objective was to examine cross-sectional and prospective relations between baseline sex hormones and mobility limitations and physical performance in community-dwelling older men. Design, Setting, and Participants: We conducted cross-sectional and longitudinal analyses of 1445 men (mean age 61.0 ± 9.5 yr) who attended Framingham Offspring Study examinations 7 and 8 (mean 6.6 yr apart). Total testosterone (TT) was measured by liquid chromatography tandem mass spectrometry at examination 7. Cross-sectionalandlongitudinal analyses of mobility limitationand physical performance were performed with continuous (per SD) and dichotomized [low TT and free testosterone (FT) and high SHBG vs. normal] hormone levels. Main Outcome Measures: Self-reported mobility limitation, subjective health, usual walking speed,andgrip strengthwereassessed at examinations 7and8. Short physical performance battery was performed at examination 7. Results: Higher continuous FT was positively associated with short physical performance battery score (β = 0.13; P = 0.008), usual walking speed (β = 0.02; P = 0.048), and lower risk of poor subjective health [odds ratio (OR) = 0.72; P = 0.01]. In prospective analysis, 1 SD increase in baseline FT was associated with lower risk of developing mobility limitation (OR = 0.78; 95% confidence interval = 0.62-0.97) and progression of mobility limitation (OR = 0.75;95%confidence interval = 0.60-0.93). Men with low baseline FT had 57% higher odds of reporting incident mobility limitation (P = 0.03) and 68% higher odds of worsening of mobility limitation (P = 0.007). Conclusions: Lower levels of baseline FT are associated with a greater risk of incident or worsening mobility limitation in community-dwelling older men. Whether this risk can be reduced with testosterone therapy needs to be determined by randomized trials.
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U2 - 10.1210/jc.2009-2680
DO - 10.1210/jc.2009-2680
M3 - Article
C2 - 20382680
AN - SCOPUS:77954484022
SN - 0021-972X
VL - 95
SP - 2790
EP - 2799
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 6
ER -