Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase

Bernard P. Arulanandam, Senthilnath Lakshmana Chetty, Jieh Juen Yu, Sean Leonard, Karl Klose, Janakiram Seshu, Andrew Cap, James J. Valdes, James P. Chambers

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: Pulmonary Francisella infection resulted in reduction of plasma alkaline phosphatase activity. Results: Francisella heat shock protein DnaK binds to alkaline phosphatase thus reducing enzymatic activity. Conclusion: A Francisella protein component responsible for alkaline phosphatase inhibition was identified. Significance: We present a novel mechanism used by a bacterial pathogen to evade the host's defense.

Original languageEnglish (US)
Pages (from-to)37185-37194
Number of pages10
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Arulanandam, B. P., Chetty, S. L., Yu, J. J., Leonard, S., Klose, K., Seshu, J., Cap, A., Valdes, J. J., & Chambers, J. P. (2012). Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase. Journal of Biological Chemistry, 287(44), 37185-37194. https://doi.org/10.1074/jbc.M112.404400