Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase

Bernard P. Arulanandam, Senthilnath Lakshmana Chetty, Jieh Juen Yu, Sean Leonard, Karl Klose, Janakiram Seshu, Andrew Cap, James J. Valdes, James P. Chambers

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Pulmonary Francisella infection resulted in reduction of plasma alkaline phosphatase activity. Results: Francisella heat shock protein DnaK binds to alkaline phosphatase thus reducing enzymatic activity. Conclusion: A Francisella protein component responsible for alkaline phosphatase inhibition was identified. Significance: We present a novel mechanism used by a bacterial pathogen to evade the host's defense.

Original languageEnglish (US)
Pages (from-to)37185-37194
Number of pages10
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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