Framingham Stroke Risk Profile and Lowered Cognitive Performance

Merrill F. Elias, Lisa M. Sullivan, Ralph B. D'Agostino, Penelope K. Elias, Alexa Beiser, Rhoda Au, Sudha Seshadri, Charles DeCarli, Philip A. Wolf

Research output: Contribution to journalArticlepeer-review

204 Scopus citations


Background and Purpose - The primary objective of this work was to describe the relationships between 10-year risk for stroke and multiple measures of cognitive performance for a large community-based sample of individuals who were free of clinical stroke and dementia at the time of risk assessment. Methods - Participants were 1011 men and 1164 women from the Framingham Offspring Study. The Framingham Stroke Risk Profile was used to assess 10-year risk of stroke. Using a cross-sectional design, we assessed 10-year risk of stroke, the predictor variable, and cognitive performance, the outcome variable, at examination 7 of the Framingham Offspring Study. Multivariable linear regression models were used to relate 10-year risk of stroke to cognitive tests measuring multiple domains of cognitive functioning. Results - With statistical adjustment for age, education, sex, and other correlates of both stroke and cognitive ability, an inverse association between increments in 10-year risk of stroke and cognitive performance level was observed for tests indexing visual-spatial memory, attention, organization, scanning, and abstract reasoning. Conclusions - In stroke- and dementia-free individuals, higher 10-year risk for stroke is associated with performance decrements in multiple cognitive domains.

Original languageEnglish (US)
Pages (from-to)404-409
Number of pages6
Issue number2
StatePublished - Feb 2004
Externally publishedYes


  • Cognition
  • Risk factors
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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