Framingham Heart Study: JACC Focus Seminar, 1/8

Charlotte Andersson, Matthew Nayor, Connie W. Tsao, Daniel Levy, Ramachandran S. Vasan

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


The Framingham Heart Study is the longest-running cardiovascular epidemiological study, starting in 1948. This paper gives an overview of the various cohorts, collected data, and most important research findings to date. In brief, the Framingham Heart Study, funded by the National Institutes of Health and managed by Boston University, spans 3 generations of well phenotyped White persons and 2 cohorts comprised of racial and ethnic minority groups. These cohorts are densely phenotyped, with extensive longitudinal follow-up, and they continue to provide us with important information on human cardiovascular and noncardiovascular physiology over the lifespan, as well as to identify major risk factors for cardiovascular disease. This paper also summarizes some of the more recent progress in molecular epidemiology and discusses the future of the study.

Original languageEnglish (US)
Pages (from-to)2680-2692
Number of pages13
JournalJournal of the American College of Cardiology
Issue number21
StatePublished - Jun 1 2021
Externally publishedYes


  • Framingham Heart Study
  • cardiovascular epidemiology
  • molecular epidemiology
  • risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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