Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1275-1286 |
| Number of pages | 12 |
| Journal | Cell |
| Volume | 129 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jun 29 2007 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
Cite this
FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene. / Zuo, Tao; Wang, Lizhong; Morrison, Carl; Chang, Xing; Zhang, Huiming; Li, Weiquan; Liu, Yan; Wang, Yin; Liu, Xingluo; Chan, Michael W Y; Liu, Jin Qing; Love, Richard; Liu, Chang gong; Godfrey, Virginia; Shen, Rulong; Huang, Hui-ming; Yang, Tianyu; Park, Bae Keun; Wang, Cun Yu; Zheng, Pan; Liu, Yang.
In: Cell, Vol. 129, No. 7, 29.06.2007, p. 1275-1286.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene
AU - Zuo, Tao
AU - Wang, Lizhong
AU - Morrison, Carl
AU - Chang, Xing
AU - Zhang, Huiming
AU - Li, Weiquan
AU - Liu, Yan
AU - Wang, Yin
AU - Liu, Xingluo
AU - Chan, Michael W Y
AU - Liu, Jin Qing
AU - Love, Richard
AU - Liu, Chang gong
AU - Godfrey, Virginia
AU - Shen, Rulong
AU - Huang, Hui-ming
AU - Yang, Tianyu
AU - Park, Bae Keun
AU - Wang, Cun Yu
AU - Zheng, Pan
AU - Liu, Yang
PY - 2007/6/29
Y1 - 2007/6/29
N2 - The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3sf/+) developed cancer at a high rate. The majority of the cancers were mammary carcinomas in which the wild-type Foxp3 allele was inactivated and HER-2/ErbB2 was overexpressed. Foxp3 bound and repressed the HER-2/ErbB2 promoter. Deletion, functionally significant somatic mutations, and downregulation of the FOXP3 gene were commonly found in human breast cancer samples and correlated significantly with HER-2/ErbB2 overexpression, regardless of the status of HER-2 amplification. Our data demonstrate that FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 oncogene.
AB - The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3sf/+) developed cancer at a high rate. The majority of the cancers were mammary carcinomas in which the wild-type Foxp3 allele was inactivated and HER-2/ErbB2 was overexpressed. Foxp3 bound and repressed the HER-2/ErbB2 promoter. Deletion, functionally significant somatic mutations, and downregulation of the FOXP3 gene were commonly found in human breast cancer samples and correlated significantly with HER-2/ErbB2 overexpression, regardless of the status of HER-2 amplification. Our data demonstrate that FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 oncogene.
KW - HUMDISEASE
UR - http://www.scopus.com/inward/record.url?scp=34250863911&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250863911&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2007.04.034
DO - 10.1016/j.cell.2007.04.034
M3 - Article
C2 - 17570480
AN - SCOPUS:34250863911
VL - 129
SP - 1275
EP - 1286
JO - Cell
JF - Cell
SN - 0092-8674
IS - 7
ER -