FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene

Tao Zuo, Lizhong Wang, Carl Morrison, Xing Chang, Huiming Zhang, Weiquan Li, Yan Liu, Yin Wang, Xingluo Liu, Michael W.Y. Chan, Jin Qing Liu, Richard Love, Chang gong Liu, Virginia Godfrey, Rulong Shen, Tim H.M. Huang, Tianyu Yang, Bae Keun Park, Cun Yu Wang, Pan ZhengYang Liu

Research output: Contribution to journalArticle

287 Scopus citations

Abstract

The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3sf/+) developed cancer at a high rate. The majority of the cancers were mammary carcinomas in which the wild-type Foxp3 allele was inactivated and HER-2/ErbB2 was overexpressed. Foxp3 bound and repressed the HER-2/ErbB2 promoter. Deletion, functionally significant somatic mutations, and downregulation of the FOXP3 gene were commonly found in human breast cancer samples and correlated significantly with HER-2/ErbB2 overexpression, regardless of the status of HER-2 amplification. Our data demonstrate that FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 oncogene.

Original languageEnglish (US)
Pages (from-to)1275-1286
Number of pages12
JournalCell
Volume129
Issue number7
DOIs
StatePublished - Jun 29 2007

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Keywords

  • HUMDISEASE

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Zuo, T., Wang, L., Morrison, C., Chang, X., Zhang, H., Li, W., Liu, Y., Wang, Y., Liu, X., Chan, M. W. Y., Liu, J. Q., Love, R., Liu, C. G., Godfrey, V., Shen, R., Huang, T. H. M., Yang, T., Park, B. K., Wang, C. Y., ... Liu, Y. (2007). FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene. Cell, 129(7), 1275-1286. https://doi.org/10.1016/j.cell.2007.04.034