FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene

Tao Zuo, Lizhong Wang, Carl Morrison, Xing Chang, Huiming Zhang, Weiquan Li, Yan Liu, Yin Wang, Xingluo Liu, Michael W Y Chan, Jin Qing Liu, Richard Love, Chang gong Liu, Virginia Godfrey, Rulong Shen, Hui-ming Huang, Tianyu Yang, Bae Keun Park, Cun Yu Wang, Pan ZhengYang Liu

Research output: Contribution to journalArticle

281 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)1275-1286
Number of pages12
JournalCell
Volume129
Issue number7
DOIs
StatePublished - Jun 29 2007
Externally publishedYes

Fingerprint

Tumor Suppressor Genes
Oncogenes
Genes
Breast Neoplasms
Winged-Helix Transcription Factors
Mutation
Amplification
Germ-Line Mutation
Autoimmune Diseases
Down-Regulation
Alleles
Neoplasms

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Zuo, T., Wang, L., Morrison, C., Chang, X., Zhang, H., Li, W., ... Liu, Y. (2007). FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene. Cell, 129(7), 1275-1286. https://doi.org/10.1016/j.cell.2007.04.034

FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene. / Zuo, Tao; Wang, Lizhong; Morrison, Carl; Chang, Xing; Zhang, Huiming; Li, Weiquan; Liu, Yan; Wang, Yin; Liu, Xingluo; Chan, Michael W Y; Liu, Jin Qing; Love, Richard; Liu, Chang gong; Godfrey, Virginia; Shen, Rulong; Huang, Hui-ming; Yang, Tianyu; Park, Bae Keun; Wang, Cun Yu; Zheng, Pan; Liu, Yang.

In: Cell, Vol. 129, No. 7, 29.06.2007, p. 1275-1286.

Research output: Contribution to journalArticle

Zuo, T, Wang, L, Morrison, C, Chang, X, Zhang, H, Li, W, Liu, Y, Wang, Y, Liu, X, Chan, MWY, Liu, JQ, Love, R, Liu, CG, Godfrey, V, Shen, R, Huang, H, Yang, T, Park, BK, Wang, CY, Zheng, P & Liu, Y 2007, 'FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene', Cell, vol. 129, no. 7, pp. 1275-1286. https://doi.org/10.1016/j.cell.2007.04.034
Zuo, Tao ; Wang, Lizhong ; Morrison, Carl ; Chang, Xing ; Zhang, Huiming ; Li, Weiquan ; Liu, Yan ; Wang, Yin ; Liu, Xingluo ; Chan, Michael W Y ; Liu, Jin Qing ; Love, Richard ; Liu, Chang gong ; Godfrey, Virginia ; Shen, Rulong ; Huang, Hui-ming ; Yang, Tianyu ; Park, Bae Keun ; Wang, Cun Yu ; Zheng, Pan ; Liu, Yang. / FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene. In: Cell. 2007 ; Vol. 129, No. 7. pp. 1275-1286.
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abstract = "The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the {"}scurfin{"} mutation of the Foxp3 gene (Foxp3sf/+) developed cancer at a high rate. The majority of the cancers were mammary carcinomas in which the wild-type Foxp3 allele was inactivated and HER-2/ErbB2 was overexpressed. Foxp3 bound and repressed the HER-2/ErbB2 promoter. Deletion, functionally significant somatic mutations, and downregulation of the FOXP3 gene were commonly found in human breast cancer samples and correlated significantly with HER-2/ErbB2 overexpression, regardless of the status of HER-2 amplification. Our data demonstrate that FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 oncogene.",
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AU - Liu, Yan

AU - Wang, Yin

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AU - Love, Richard

AU - Liu, Chang gong

AU - Godfrey, Virginia

AU - Shen, Rulong

AU - Huang, Hui-ming

AU - Yang, Tianyu

AU - Park, Bae Keun

AU - Wang, Cun Yu

AU - Zheng, Pan

AU - Liu, Yang

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N2 - The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3sf/+) developed cancer at a high rate. The majority of the cancers were mammary carcinomas in which the wild-type Foxp3 allele was inactivated and HER-2/ErbB2 was overexpressed. Foxp3 bound and repressed the HER-2/ErbB2 promoter. Deletion, functionally significant somatic mutations, and downregulation of the FOXP3 gene were commonly found in human breast cancer samples and correlated significantly with HER-2/ErbB2 overexpression, regardless of the status of HER-2 amplification. Our data demonstrate that FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 oncogene.

AB - The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3sf/+) developed cancer at a high rate. The majority of the cancers were mammary carcinomas in which the wild-type Foxp3 allele was inactivated and HER-2/ErbB2 was overexpressed. Foxp3 bound and repressed the HER-2/ErbB2 promoter. Deletion, functionally significant somatic mutations, and downregulation of the FOXP3 gene were commonly found in human breast cancer samples and correlated significantly with HER-2/ErbB2 overexpression, regardless of the status of HER-2 amplification. Our data demonstrate that FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 oncogene.

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