Abstract
Forkhead transcription factors are key participants in development and immune regulation. Here we demonstrate that absence of the gene encoding the forkhead transcription factor Foxp1 resulted in a profound defect in early B cell development. Foxp1 deficiency was associated with decreased expression of all B lineage genes in B220+ fetal liver cells as well as with a block in the transition from pro-B cell to pre-B cell involving diminished expression of recombination-activating genes 1 and 2. Foxp1 bound to the Erag enhancer and was involved in controlling variable-(diversity)-joining recombination of the gene encoding immunoglobulin heavy chain in a B cell lineage-specific way. Our results identify Foxp1 as an essential participant in the transcriptional regulatory network of B lymphopoiesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 819-826 |
| Number of pages | 8 |
| Journal | Nature Immunology |
| Volume | 7 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2006 |
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ASJC Scopus subject areas
- Immunology
Cite this
Foxp1 is an essential transcriptional regulator of B cell development. / Hu, Hui; Wang, Bin; Borde, Madhuri; Nardone, Julie; Maika, Shan; Allred, Laura; Tucker, Philip W.; Rao, Anjana.
In: Nature Immunology, Vol. 7, No. 8, 08.2006, p. 819-826.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Foxp1 is an essential transcriptional regulator of B cell development
AU - Hu, Hui
AU - Wang, Bin
AU - Borde, Madhuri
AU - Nardone, Julie
AU - Maika, Shan
AU - Allred, Laura
AU - Tucker, Philip W.
AU - Rao, Anjana
PY - 2006/8
Y1 - 2006/8
N2 - Forkhead transcription factors are key participants in development and immune regulation. Here we demonstrate that absence of the gene encoding the forkhead transcription factor Foxp1 resulted in a profound defect in early B cell development. Foxp1 deficiency was associated with decreased expression of all B lineage genes in B220+ fetal liver cells as well as with a block in the transition from pro-B cell to pre-B cell involving diminished expression of recombination-activating genes 1 and 2. Foxp1 bound to the Erag enhancer and was involved in controlling variable-(diversity)-joining recombination of the gene encoding immunoglobulin heavy chain in a B cell lineage-specific way. Our results identify Foxp1 as an essential participant in the transcriptional regulatory network of B lymphopoiesis.
AB - Forkhead transcription factors are key participants in development and immune regulation. Here we demonstrate that absence of the gene encoding the forkhead transcription factor Foxp1 resulted in a profound defect in early B cell development. Foxp1 deficiency was associated with decreased expression of all B lineage genes in B220+ fetal liver cells as well as with a block in the transition from pro-B cell to pre-B cell involving diminished expression of recombination-activating genes 1 and 2. Foxp1 bound to the Erag enhancer and was involved in controlling variable-(diversity)-joining recombination of the gene encoding immunoglobulin heavy chain in a B cell lineage-specific way. Our results identify Foxp1 as an essential participant in the transcriptional regulatory network of B lymphopoiesis.
UR - http://www.scopus.com/inward/record.url?scp=33746150775&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746150775&partnerID=8YFLogxK
U2 - 10.1038/ni1358
DO - 10.1038/ni1358
M3 - Article
C2 - 16819554
AN - SCOPUS:33746150775
VL - 7
SP - 819
EP - 826
JO - Nature Immunology
JF - Nature Immunology
SN - 1529-2908
IS - 8
ER -