Abstract
Forkhead transcription factors are key participants in development and immune regulation. Here we demonstrate that absence of the gene encoding the forkhead transcription factor Foxp1 resulted in a profound defect in early B cell development. Foxp1 deficiency was associated with decreased expression of all B lineage genes in B220+ fetal liver cells as well as with a block in the transition from pro-B cell to pre-B cell involving diminished expression of recombination-activating genes 1 and 2. Foxp1 bound to the Erag enhancer and was involved in controlling variable-(diversity)-joining recombination of the gene encoding immunoglobulin heavy chain in a B cell lineage-specific way. Our results identify Foxp1 as an essential participant in the transcriptional regulatory network of B lymphopoiesis.
Original language | English (US) |
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Pages (from-to) | 819-826 |
Number of pages | 8 |
Journal | Nature Immunology |
Volume | 7 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2006 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology