Foxp1 is an essential transcriptional regulator of B cell development

Hui Hu, Bin Wang, Madhuri Borde, Julie Nardone, Shan Maika, Laura Allred, Philip W. Tucker, Anjana Rao

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228 Scopus citations

Abstract

Forkhead transcription factors are key participants in development and immune regulation. Here we demonstrate that absence of the gene encoding the forkhead transcription factor Foxp1 resulted in a profound defect in early B cell development. Foxp1 deficiency was associated with decreased expression of all B lineage genes in B220+ fetal liver cells as well as with a block in the transition from pro-B cell to pre-B cell involving diminished expression of recombination-activating genes 1 and 2. Foxp1 bound to the Erag enhancer and was involved in controlling variable-(diversity)-joining recombination of the gene encoding immunoglobulin heavy chain in a B cell lineage-specific way. Our results identify Foxp1 as an essential participant in the transcriptional regulatory network of B lymphopoiesis.

Original languageEnglish (US)
Pages (from-to)819-826
Number of pages8
JournalNature Immunology
Volume7
Issue number8
DOIs
StatePublished - Aug 1 2006

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Hu, H., Wang, B., Borde, M., Nardone, J., Maika, S., Allred, L., Tucker, P. W., & Rao, A. (2006). Foxp1 is an essential transcriptional regulator of B cell development. Nature Immunology, 7(8), 819-826. https://doi.org/10.1038/ni1358