FOXO3A Expression in Upper Tract Urothelial Carcinoma

Guoyao Zhang, Wanping Shi, Enzhao Jia, Lei Zhang, Yongsheng Han, Ronald Rodriguez, Tianjiang Ma

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Epidemiological studies have reported various results regarding whether FOXO3A is related to various carcinomas. However, the prognostic significance of FOXO3A in upper tract urothelial carcinoma (UTUC) remains unclear. The purpose of this study was to validate the correlation between FOXO3A expression and oncological outcomes in UTUC. Methods: The expression levels of FOXO3A in 107 UTUC patients were examined by immunohistochemistry (IHC). We examined the prognostic role of FOXO3A by using the Cox proportional hazard model. Results: The results indicated that FOXO3A expression was notably decreased in UTUC tissue compared with control tissue. Decreased expression of FOXO3A was also related to advanced pathologic stage (P = 0.026), lymph node metastasis (P = 0.040), lymphovascular invasion (P < 0.001), and adjuvant therapy (P = 0.048). In addition, UTUC patients with low FOXO3A expression had a significantly shorter survival time, including both overall survival (OS) [hazard ratio (HR) 2.382, P = 0.004] and recurrence-free survival (RFS) (HR 2.385, P = 0.004), than those with high expression. Multivariate analyses showed that FOXO3A was a significant predictor for OS (HR 2.145, P = 0.014) and RFS (HR 2.227, P = 0.010) in UTUC patients. Conclusion: Our results indicate that FOXO3A may be involved in the recurrence of UTUC and that it has certain clinical value in the therapeutic targeting and prognostic evaluation of UTUC.

Original languageEnglish (US)
Article number603681
JournalFrontiers in Oncology
Volume11
DOIs
StatePublished - Apr 20 2021

Keywords

  • FOXO3A
  • overall survival
  • prognosis
  • recurrence-free survival
  • upper tract urothelial carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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