Forced over-expression of the myeloid zinc finger gene MZF-1 inhibits apoptosis and promotes oncogenesis in interleukin-3-dependent FDCP.1 cells

R. Hromas; S. Boswell; R. N. Shen; G. Burgess; A. Davidson; K. Cornetta; J. Sutton; K. Robertson

Forced over-expression of the myeloid zinc finger gene MZF-1 inhibits apoptosis and promotes oncogenesis in interleukin-3-dependent FDCP.1 cells

R. Hromas, S. Boswell, R. N. Shen, G. Burgess, A. Davidson, K. Cornetta, J. Sutton, K. Robertson

Research output: Contribution to journal › Article › peer-review

Abstract

The myeloid zinc finger protein MZF-1 is important in hematopoiesis. Previous studies have found that reducing expression of MZF-1 inhibited G-CSF-driven human marrow colony formation assays. In this study we found that retrovirally overexpressing MZF-1 in IL-3 dependent FDCP.1 cells inhibited their apoptosis when IL-3 was withdrawn. The MZF-1-transduced FDCP.1 cells also formed tumors when injected into congenic mice, whereas control FDCP.1 cells did not.

Original language	English (US)
Pages (from-to)	1049-1050
Number of pages	2
Journal	Leukemia
Volume	10
Issue number	6
State	Published - Jun 1996
Externally published	Yes

Keywords

Apoptosis
Oncogenesis
Retroviral gene transfer
Transcription factors

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Cite this

Forced over-expression of the myeloid zinc finger gene MZF-1 inhibits apoptosis and promotes oncogenesis in interleukin-3-dependent FDCP.1 cells. / Hromas, R.; Boswell, S.; Shen, R. N.; Burgess, G.; Davidson, A.; Cornetta, K.; Sutton, J.; Robertson, K.

In: Leukemia, Vol. 10, No. 6, 06.1996, p. 1049-1050.

Research output: Contribution to journal › Article › peer-review

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abstract = "The myeloid zinc finger protein MZF-1 is important in hematopoiesis. Previous studies have found that reducing expression of MZF-1 inhibited G-CSF-driven human marrow colony formation assays. In this study we found that retrovirally overexpressing MZF-1 in IL-3 dependent FDCP.1 cells inhibited their apoptosis when IL-3 was withdrawn. The MZF-1-transduced FDCP.1 cells also formed tumors when injected into congenic mice, whereas control FDCP.1 cells did not.",

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AU - Hromas, R.

AU - Boswell, S.

AU - Shen, R. N.

AU - Burgess, G.

AU - Davidson, A.

AU - Cornetta, K.

AU - Sutton, J.

AU - Robertson, K.

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N2 - The myeloid zinc finger protein MZF-1 is important in hematopoiesis. Previous studies have found that reducing expression of MZF-1 inhibited G-CSF-driven human marrow colony formation assays. In this study we found that retrovirally overexpressing MZF-1 in IL-3 dependent FDCP.1 cells inhibited their apoptosis when IL-3 was withdrawn. The MZF-1-transduced FDCP.1 cells also formed tumors when injected into congenic mice, whereas control FDCP.1 cells did not.

AB - The myeloid zinc finger protein MZF-1 is important in hematopoiesis. Previous studies have found that reducing expression of MZF-1 inhibited G-CSF-driven human marrow colony formation assays. In this study we found that retrovirally overexpressing MZF-1 in IL-3 dependent FDCP.1 cells inhibited their apoptosis when IL-3 was withdrawn. The MZF-1-transduced FDCP.1 cells also formed tumors when injected into congenic mice, whereas control FDCP.1 cells did not.

KW - Apoptosis

KW - Oncogenesis

KW - Retroviral gene transfer

KW - Transcription factors

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Forced over-expression of the myeloid zinc finger gene MZF-1 inhibits apoptosis and promotes oncogenesis in interleukin-3-dependent FDCP.1 cells

Abstract

Keywords

ASJC Scopus subject areas

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