Abstract
The myeloid zinc finger protein MZF-1 is important in hematopoiesis. Previous studies have found that reducing expression of MZF-1 inhibited G-CSF-driven human marrow colony formation assays. In this study we found that retrovirally overexpressing MZF-1 in IL-3 dependent FDCP.1 cells inhibited their apoptosis when IL-3 was withdrawn. The MZF-1-transduced FDCP.1 cells also formed tumors when injected into congenic mice, whereas control FDCP.1 cells did not.
Original language | English (US) |
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Pages (from-to) | 1049-1050 |
Number of pages | 2 |
Journal | Leukemia |
Volume | 10 |
Issue number | 6 |
State | Published - Jun 1996 |
Externally published | Yes |
Keywords
- Apoptosis
- Oncogenesis
- Retroviral gene transfer
- Transcription factors
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research