Forced expiration and HeO2 response in canine peripheral airway obstruction

C. Jadue, H. Greville, J. J. Coalson, S. N. Mink

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We examined the effect of peripheral airway obstruction on parameters of maximum expiratory flow (Vmax) in a canine model of bronchiolitis obliterans (B). B was produced by the repeated intrabronchial instillations of a 1% nitric acid solution in seven dogs (group B). In seven control dogs (group C), a normal saline solution was used. During forced vital capacity deflation, Vmax on air, the relative increase in Vmax on 80% He-20% O2 (ΔVmax), and airway sites of flow limitation 'choke points' (CP) were determined at multiple lung volumes (VL). The findings were interpreted in terms of the wave-speed theory of flow limitation. Wave-speed parameters were identified with a pressure-measuring device positioned in the airway. Compared with the findings for group C, Vmax decreased substantially at the lower VL (<50% vital capacity) in group B, whereas there were no changes in ΔVmax at any VL. CP were identified in central airways in both groups but were slightly more upstream in group B. Our analysis indicated that the reduction in Vmax in group B was due to an increase in upstream frictional pressure losses (Pfr) that caused a relative reduction in the pressure head, so that choking occurred in slightly upstream airways. ΔVmax did not change in group B because with CP identified in central airways, Pfr were density dependent, and significant differences in head loss on the two gas mixtures did not occur. Choking therefore occurred with similar wave-speed variables on the two gas mixtures, and ΔVmax was maintained.

Original languageEnglish (US)
Pages (from-to)1788-1801
Number of pages14
JournalJournal of Applied Physiology
Volume58
Issue number6
StatePublished - 1985
Externally publishedYes

Fingerprint

Airway Obstruction
Canidae
Vital Capacity
Pressure
Gases
Dogs
Bronchiolitis Obliterans
Nitric Acid
Sodium Chloride
Air
Head
Equipment and Supplies
Lung
Control Groups

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Jadue, C., Greville, H., Coalson, J. J., & Mink, S. N. (1985). Forced expiration and HeO2 response in canine peripheral airway obstruction. Journal of Applied Physiology, 58(6), 1788-1801.

Forced expiration and HeO2 response in canine peripheral airway obstruction. / Jadue, C.; Greville, H.; Coalson, J. J.; Mink, S. N.

In: Journal of Applied Physiology, Vol. 58, No. 6, 1985, p. 1788-1801.

Research output: Contribution to journalArticle

Jadue, C, Greville, H, Coalson, JJ & Mink, SN 1985, 'Forced expiration and HeO2 response in canine peripheral airway obstruction', Journal of Applied Physiology, vol. 58, no. 6, pp. 1788-1801.
Jadue, C. ; Greville, H. ; Coalson, J. J. ; Mink, S. N. / Forced expiration and HeO2 response in canine peripheral airway obstruction. In: Journal of Applied Physiology. 1985 ; Vol. 58, No. 6. pp. 1788-1801.
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