Food deprivation increases oral and intravenous drug intake in rats

Marilyn E. Carroll, Charles P. France, Richard A. Meisch

Research output: Contribution to journalArticle

188 Scopus citations

Abstract

Rats given continuous access to etonitazene hydrochloride in their drinking water (5 micrograms per milliliter) more than doubled their drug intake while deprived of food. Another group of rats with implanted jugular catheters self-administered etonitazene (10 micrograms per kilogram) intravenously on a continuous reinforcement schedule, and the number of infusions increased significantly on days when they were deprived of food. These results suggest that feeding condition may be a powerful determinant of drug-reinforced behavior.

Original languageEnglish (US)
Pages (from-to)319-321
Number of pages3
JournalScience
Volume205
Issue number4403
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

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