Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene

A. Ruiz, S. Heilmann, T. Becker, I. Hernández, H. Wagner, M. Thelen, A. Mauleón, M. Rosende-Roca, C. Bellenguez, J. C. Bis, D. Harold, A. Gerrish, R. Sims, O. Sotolongo-Grau, A. Espinosa, M. Alegret, J. L. Arrieta, A. Lacour, M. Leber, J. BeckerA. Lafuente, S. Ruiz, L. Vargas, O. Rodríguez, G. Ortega, M. A. Dominguez, R. Mayeux, J. L. Haines, M. A. Pericak-Vance, L. A. Farrer, G. D. Schellenberg, V. Chouraki, L. J. Launer, C. Van Duijn, S. Seshadri, C. Antúnez, M. M. Breteler, M. Serrano-Ríos, F. Jessen, L. Tárraga, M. M. Nöthen, W. Maier, M. Boada, A. L. Ramírez

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

To follow-up loci discovered by the International Genomics of Alzheimer's Disease Project, we attempted independent replication of 19 single nucleotide polymorphisms (SNPs) in a large Spanish sample (Fundació ACE data set; 1808 patients and 2564 controls). Our results corroborate association with four SNPs located in the genes INPP5D, MEF2C, ZCWPW1 and FERMT2, respectively. Of these, ZCWPW1 was the only SNP to withstand correction for multiple testing (P=0.000655). Furthermore, we identify TRIP4 (rs74615166) as a novel genome-wide significant locus for Alzheimer's disease risk (odds ratio=1.31; confidence interval 95% (1.19-1.44); P=9.74 × 10 - 9).

Original languageEnglish (US)
Article number20142
JournalTranslational psychiatry
Volume4
DOIs
StatePublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Biological Psychiatry

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    Ruiz, A., Heilmann, S., Becker, T., Hernández, I., Wagner, H., Thelen, M., Mauleón, A., Rosende-Roca, M., Bellenguez, C., Bis, J. C., Harold, D., Gerrish, A., Sims, R., Sotolongo-Grau, O., Espinosa, A., Alegret, M., Arrieta, J. L., Lacour, A., Leber, M., ... Ramírez, A. L. (2014). Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene. Translational psychiatry, 4, [20142]. https://doi.org/10.1038/tp.2014.2