Abstract
Purpose: Focal cerebral cooling has been shown to reduce epileptiform activity in animals. There are, however, few reports of this phenomenon in humans. Methods: Electrocorticography was performed before resection of a right frontal tumor in a patient with partial seizures. Cold saline was applied to the interictal spike focus, and its effect on the epileptiform discharges was observed. Results: Application of cold saline to the spike focus resulted in a transient, complete cessation of spiking. This effect was reproduced with a second application of cold saline. The motor threshold for electrical stimulation remained unchanged during the application of saline. Conclusions: In this patient with tumor-related epilepsy, focal cooling of the cortex reproducibly abolished interictal epileptiform discharges without changing the motor threshold to electrical stimulation.
Original language | English (US) |
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Pages (from-to) | 932-935 |
Number of pages | 4 |
Journal | Epilepsia |
Volume | 43 |
Issue number | 8 |
DOIs | |
State | Published - 2002 |
Externally published | Yes |
Keywords
- Cerebral cooling
- Epileptiform
- Motor threshold
ASJC Scopus subject areas
- Clinical Neurology
- Neurology