fMRI evidence of aberrant neural adaptation for objects in schizophrenia and bipolar disorder

Junghee Lee, Eric A. Reavis, Stephen A. Engel, Lori L. Altshuler, Mark S. Cohen, David C. Glahn, Keith H. Nuechterlein, Jonathan K. Wynn, Michael F. Green

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Functional magnetic resonance imaging (fMRI) adaptation (also known as fMRI repetition suppression) has been widely used to characterize stimulus selectivity in vivo, a fundamental feature of neuronal processing in the brain. We investigated whether SZ patients and BD patients show aberrant fMRI adaptation for object perception. About 52 SZ patients, 55 BD patients, and 53 community controls completed an object discrimination task with three conditions: the same object presented twice, two exemplars from the same category, and two exemplars from different categories. We also administered two functional localizer tasks. A region of interest analysis was employed to evaluate a priori hypotheses about the lateral occipital complex (LOC) and early visual cortex (EVC). An exploratory whole brain analysis was also conducted. In the LOC and EVC, controls showed the expected reduced fMRI responses to repeated presentation of the same objects compared with different objects (i.e., fMRI adaptation for objects, p <.001). SZ patients showed an adaptation effect that was significantly smaller compared with controls. BD patients showed a lack of fMRI adaptation. The whole brain analyses showed enhanced fMRI responses to repeated presentation of the same objects only in BD patients in several brain regions including anterior cingulate cortex. This study was the first to employ fMRI adaptation for objects in SZ and BD. The current findings provide empirical evidence of aberrant fMRI adaptation in the visual cortex in SZ and BD, but in distinctly different ways.

Original languageEnglish (US)
Pages (from-to)1608-1617
Number of pages10
JournalHuman Brain Mapping
Volume40
Issue number5
DOIs
StatePublished - Apr 1 2019
Externally publishedYes

Keywords

  • bipolar disorder
  • fMRI adaptation
  • neural tuning
  • object processing
  • schizophrenia

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'fMRI evidence of aberrant neural adaptation for objects in schizophrenia and bipolar disorder'. Together they form a unique fingerprint.

Cite this