Fluvoxamine/Pimozide treatment of concurrent Tourette's and obsessive-compulsive disorder

P. L. Delgado, W. K. Goodman, L. H. Price, G. R. Heninger, D. S. Charney

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


A 25-year-old man with a history of Tourette's syndrome presented for treatment of OCD symptoms. Fluvoxamine worsened tics, led to coprolalia, and did not help the OCD. The addition of pimozide dramatically reduced both OCD and Tourette's symptoms. Double-blind sequential discontinuation of fluvoxamine and pimozide confirmed that pimozide alone reduced only tics and the combination of fluvoxamine and pimozide was required for the improvement in OCD. Tics may reflect a subtype of OCD. Some OCD patients unresponsive to a 5-HT reuptake inhibitor alone may benefit from the addition of a dopamine antagonist.

Original languageEnglish (US)
Pages (from-to)762-765
Number of pages4
JournalBritish Journal of Psychiatry
Issue numberNOV.
StatePublished - 1990

ASJC Scopus subject areas

  • Psychiatry and Mental health


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