Fluphenazine levels during maintenance treatment of recent-onset schizophrenia: Relation to side effects, psychosocial function and depression

Michael J. Gitlin, Keith H. Nuechterlein, Jim Mintz, David Fogelson, George Bartzokis, Joseph Ventura, Kenneth Subotnik, Manickam Aravagiri

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Rationale: The utility of fluphenazine levels during maintenance treatment of schizophrenia is still unclear. Objectives: This study investigated the relationship between fluphenazine levels and a variety of clinical measures during maintenance treatment of schizophrenia. Methods: Fluphenazine levels, side effects, depression and psychosocial outcome were measured at five time points over approximately 1 year in 59 recent onset schizophrenic patients treated with a maintenance dose of injectable fluphenazine decanoate. Negative symptoms were evaluated at the 1-year endpoint. Results: Fluphenazine levels showed marked intraindividual variability even when measurements were restricted to the second 6 months of treatment, by which time steady state levels should have been achieved. No consistent relationship was found between fluphenazine levels and any of the outcome measures. Conclusions: The results of this study suggest that fluphenazine plasma levels do not routinely add relevant clinical information beyond that of dose in evaluating potential side effects or negative consequences during maintenance treatment with the decanoate form of the medication.

Original languageEnglish (US)
Pages (from-to)350-354
Number of pages5
JournalPsychopharmacology
Volume148
Issue number4
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Keywords

  • Fluphenazine plasma levels
  • Neuroleptic side effects
  • Neuroleptic treatment
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Fluphenazine levels during maintenance treatment of recent-onset schizophrenia: Relation to side effects, psychosocial function and depression'. Together they form a unique fingerprint.

Cite this