Fluoxetine disrupts food intake and estrous cyclicity in Fischer female rats

Lynda Uphouse, Julie G. Hensler, Jhimly Sarkar, Bruce Grossie

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Adult, regularly cycling female Fischer rats were injected daily with 10 mg/kg fluoxetine for 12-23 days. In the first experiment, body weight and vaginal smears were monitored daily. Fluoxetine treatment reduced body weight within the first 24 h of treatment. Fluoxetine treatment also elongated the estrous cycle, reduced blood levels of progesterone, and eliminated lordosis behavior. In the second experiment, body weight and food intake were examined and a pair-fed group was included to determine if fluoxetine-induced anorexia contributed to the disturbance of the estrous cycle. In pair-fed rats, effects similar to fluoxetine treatment were present. These results lead to the suggestion that fluoxetine's anorectic properties could disrupt the female's normal endocrine cyclicity and that this disruption could be relevant to the reduction in sexual behavior and motivation. However, when the duration of fluoxetine treatment was extended beyond 16 to 17 days, fluoxetine-treated female rats reinitiated vaginal cyclicity and showed evidence of normal sexual receptivity. In contrast, the estrous cycles of their pair-fed counterparts remained disrupted. Thus, restricted food intake appears to contribute to the disruption of the estrous cycle and elimination of sexual receptivity during fluoxetine treatment. However, compensatory changes in the serotonergic system that are associated with chronic fluoxetine administration may contribute to the gradual recovery of estrous cyclicity and sexual receptivity of the fluoxetine-treated animals.

Original languageEnglish (US)
Pages (from-to)79-90
Number of pages12
JournalBrain Research
Volume1072
Issue number1
DOIs
StatePublished - Feb 9 2006

Fingerprint

Fluoxetine
Inbred F344 Rats
Periodicity
Eating
Estrous Cycle
Body Weight
Appetite Depressants
Lordosis
Vaginal Smears
Anorexia
Sexual Behavior
Progesterone
Motivation

Keywords

  • Food restriction
  • Hormone
  • Lordosis
  • Progesterone
  • Sexual dysfunction
  • SSRIs

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Fluoxetine disrupts food intake and estrous cyclicity in Fischer female rats. / Uphouse, Lynda; Hensler, Julie G.; Sarkar, Jhimly; Grossie, Bruce.

In: Brain Research, Vol. 1072, No. 1, 09.02.2006, p. 79-90.

Research output: Contribution to journalArticle

Uphouse, Lynda ; Hensler, Julie G. ; Sarkar, Jhimly ; Grossie, Bruce. / Fluoxetine disrupts food intake and estrous cyclicity in Fischer female rats. In: Brain Research. 2006 ; Vol. 1072, No. 1. pp. 79-90.
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