TY - GEN
T1 - Fluorescence imaging of early lung cancer
AU - Lam, S.
AU - Hung, J.
AU - MacAulay, C.
AU - Jaggi, B.
AU - Palcic, B.
PY - 1990/12/1
Y1 - 1990/12/1
N2 - Using a ratio fluorometer probe, tissue autofluorescence induced by a krypton ion laser in normal bronchial tissues and early lung cancer was found to be different. In vivo spectroscopic measurements using an optical multichannel analyzer also showed an overall decrease in autofluorescence in the tumor tissues. Because tissue autofluorescence is not uniform, the technique of ratioing may not be reliably applied to bronchoscopic imaging of early lung cancer to cancel the dependence of fluorescence intensity on the distance, angle, and irradiance of the excitation light. This can, however, be overcome by other mathematical transformations of the autofluorescence images of the two spectral regions.
AB - Using a ratio fluorometer probe, tissue autofluorescence induced by a krypton ion laser in normal bronchial tissues and early lung cancer was found to be different. In vivo spectroscopic measurements using an optical multichannel analyzer also showed an overall decrease in autofluorescence in the tumor tissues. Because tissue autofluorescence is not uniform, the technique of ratioing may not be reliably applied to bronchoscopic imaging of early lung cancer to cancel the dependence of fluorescence intensity on the distance, angle, and irradiance of the excitation light. This can, however, be overcome by other mathematical transformations of the autofluorescence images of the two spectral regions.
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M3 - Conference contribution
AN - SCOPUS:0025562433
SN - 0879425598
T3 - Proceedings of the Annual Conference on Engineering in Medicine and Biology
SP - 1142
EP - 1143
BT - Biomedical Engineering Perspectives
PB - Publ by IEEE
T2 - Proceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Y2 - 1 November 1990 through 4 November 1990
ER -