Fluorescence imaging of early lung cancer

S. Lam, J. Hung, C. MacAulay, B. Jaggi, B. Palcic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Using a ratio fluorometer probe, tissue autofluorescence induced by a krypton ion laser in normal bronchial tissues and early lung cancer was found to be different. In vivo spectroscopic measurements using an optical multichannel analyzer also showed an overall decrease in autofluorescence in the tumor tissues. Because tissue autofluorescence is not uniform, the technique of ratioing may not be reliably applied to bronchoscopic imaging of early lung cancer to cancel the dependence of fluorescence intensity on the distance, angle, and irradiance of the excitation light. This can, however, be overcome by other mathematical transformations of the autofluorescence images of the two spectral regions.

Original languageEnglish (US)
Title of host publicationBiomedical Engineering Perspectives
Subtitle of host publicationHealth Care Technologies for the 1990's and Beyond
PublisherPubl by IEEE
Pages1142-1143
Number of pages2
Editionpt 3
ISBN (Print)0879425598
StatePublished - Dec 1 1990
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 3
ISSN (Print)0589-1019

Other

OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA
Period11/1/9011/4/90

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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