Fluconazole Penetration into Cerebrospinal Fluid in Humans

George Foulds; Doreen R. Brennan; Charles Wajszczuk; Antonino Catanzaro; Dyal C. Garg; William Knopf; Michael Rinaldi; Donald J. Weidler

doi:10.1002/j.1552-4604.1988.tb03159.x

Fluconazole Penetration into Cerebrospinal Fluid in Humans

George Foulds, Doreen R. Brennan, Charles Wajszczuk, Antonino Catanzaro, Dyal C. Garg, William Knopf, Michael Rinaldi, Donald J. Weidler

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

One hour after intravenous doses of 50 mg/d fluconazole for 6 days or 100 mg/d for seven days to healthy subjects, the cerebrospinal fluid concentrations of fluconazole were 1.26 mg/L and 2.74 mg/L, respectively. These values were approximately 52% and 62% those of serum. Four patients with an initial clinical diagnosis of meningitis also had significant concentrations of fluconazole in the cerebrospinal fluid. 1988 American College of Clinical Pharmacology

Original language	English (US)
Pages (from-to)	363-366
Number of pages	4
Journal	The Journal of Clinical Pharmacology
Volume	28
Issue number	4
DOIs	https://doi.org/10.1002/j.1552-4604.1988.tb03159.x
State	Published - Apr 1988
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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abstract = "One hour after intravenous doses of 50 mg/d fluconazole for 6 days or 100 mg/d for seven days to healthy subjects, the cerebrospinal fluid concentrations of fluconazole were 1.26 mg/L and 2.74 mg/L, respectively. These values were approximately 52% and 62% those of serum. Four patients with an initial clinical diagnosis of meningitis also had significant concentrations of fluconazole in the cerebrospinal fluid. 1988 American College of Clinical Pharmacology",

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AU - Brennan, Doreen R.

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AU - Catanzaro, Antonino

AU - Garg, Dyal C.

AU - Knopf, William

AU - Rinaldi, Michael

AU - Weidler, Donald J.

PY - 1988/4

Y1 - 1988/4

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AB - One hour after intravenous doses of 50 mg/d fluconazole for 6 days or 100 mg/d for seven days to healthy subjects, the cerebrospinal fluid concentrations of fluconazole were 1.26 mg/L and 2.74 mg/L, respectively. These values were approximately 52% and 62% those of serum. Four patients with an initial clinical diagnosis of meningitis also had significant concentrations of fluconazole in the cerebrospinal fluid. 1988 American College of Clinical Pharmacology

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Fluconazole Penetration into Cerebrospinal Fluid in Humans

Abstract

ASJC Scopus subject areas

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