Fluconazole Penetration into Cerebrospinal Fluid in Humans

George Foulds, Doreen R. Brennan, Charles Wajszczuk, Antonino Catanzaro, Dyal C. Garg, William Knopf, Michael Rinaldi, Donald J. Weidler

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


One hour after intravenous doses of 50 mg/d fluconazole for 6 days or 100 mg/d for seven days to healthy subjects, the cerebrospinal fluid concentrations of fluconazole were 1.26 mg/L and 2.74 mg/L, respectively. These values were approximately 52% and 62% those of serum. Four patients with an initial clinical diagnosis of meningitis also had significant concentrations of fluconazole in the cerebrospinal fluid. 1988 American College of Clinical Pharmacology

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalThe Journal of Clinical Pharmacology
Issue number4
StatePublished - Apr 1988
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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