Flow microfluorometric analysis of the cell cycle phase cytotoxicity of ara-C

R. A. Hromas; D. E. Markel; V. E. Scholes

Flow microfluorometric analysis of the cell cycle phase cytotoxicity of ara-C

R. A. Hromas, D. E. Markel, V. E. Scholes

Research output: Contribution to journal › Article › peer-review

Abstract

Mouse L1210 leukemia cells killed by ara-C, an anti-tumor agent widely used against leukemia, were demonstrated to be in the S phase of the cell cycle by flow microfluorometry. The point in S phase at which the L1210 cells died was shown to be dose dependent. At higher concentrations of ara-C cells died earlier in the S phase.

Original language	English (US)
Pages (from-to)	365-368
Number of pages	4
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	30
Issue number	2
State	Published - Dec 1 1980
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Pharmacology
Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Flow microfluorometric analysis of the cell cycle phase cytotoxicity of ara-C",

abstract = "Mouse L1210 leukemia cells killed by ara-C, an anti-tumor agent widely used against leukemia, were demonstrated to be in the S phase of the cell cycle by flow microfluorometry. The point in S phase at which the L1210 cells died was shown to be dose dependent. At higher concentrations of ara-C cells died earlier in the S phase.",

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year = "1980",

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AU - Hromas, R. A.

AU - Markel, D. E.

AU - Scholes, V. E.

PY - 1980/12/1

Y1 - 1980/12/1

N2 - Mouse L1210 leukemia cells killed by ara-C, an anti-tumor agent widely used against leukemia, were demonstrated to be in the S phase of the cell cycle by flow microfluorometry. The point in S phase at which the L1210 cells died was shown to be dose dependent. At higher concentrations of ara-C cells died earlier in the S phase.

AB - Mouse L1210 leukemia cells killed by ara-C, an anti-tumor agent widely used against leukemia, were demonstrated to be in the S phase of the cell cycle by flow microfluorometry. The point in S phase at which the L1210 cells died was shown to be dose dependent. At higher concentrations of ara-C cells died earlier in the S phase.

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AN - SCOPUS:0019197698

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ER -

Flow microfluorometric analysis of the cell cycle phase cytotoxicity of ara-C

Abstract

ASJC Scopus subject areas

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