Flow microfluorometric analysis of the cell cycle phase cytotoxicity of ara-C

R. A. Hromas, D. E. Markel, V. E. Scholes

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Mouse L1210 leukemia cells killed by ara-C, an anti-tumor agent widely used against leukemia, were demonstrated to be in the S phase of the cell cycle by flow microfluorometry. The point in S phase at which the L1210 cells died was shown to be dose dependent. At higher concentrations of ara-C cells died earlier in the S phase.

Original languageEnglish (US)
Pages (from-to)365-368
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume30
Issue number2
StatePublished - Dec 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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