Flow increases endothelial migration and inhibits smooth muscle cell proliferation in artery and co-culture models

Yong Ung Lee, Jian Luo, Eugene Sprague, Hai Chao Han

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Arterial restenosis associated with intimai hyperplasia at stent revascularization sites remains the major cause of long-term failure. The objective of this study was to determine the effect of flow in promoting endothelial cell migration and the effect of reendothelialization on smooth muscle cell (SMC) proliferation. This study demonstrated that re-endothelialization reduces SMC proliferation and migration and provides model systems to study approaches to increasing endothelial healing.

Original languageEnglish (US)
Title of host publicationProceedings of the ASME Summer Bioengineering Conference, SBC2008
Pages305-306
Number of pages2
EditionPART A
StatePublished - Dec 1 2009
Event10th ASME Summer Bioengineering Conference, SBC2008 - Marco Island, FL, United States
Duration: Jun 25 2008Jun 29 2008

Publication series

NameProceedings of the ASME Summer Bioengineering Conference, SBC2008
NumberPART A

Other

Other10th ASME Summer Bioengineering Conference, SBC2008
CountryUnited States
CityMarco Island, FL
Period6/25/086/29/08

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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