Fish techniques for constructing physical maps on schistosome chromosomes

H. Hirai, P. T. LoVerde

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

In an effort to provide useful information about parasites important in tropical diseases, the WHO has initiated genome mapping projects for a number of parasites. One goal of this effort is to establish physical maps of the genomes of the targeted parasites. Multicellular parasites (helminths) contain various numbesr of chromosomes, some large, that condense during the cell cycle. Here Hirohisa Hirai and Phil LoVerde present details of fluorescence in situ hybridization as a means to localize genes and DNA fragments to schistosome chromosomes. Although the techniques presented are for schistosome chromosomes, they are applicable to any system where the chromosomes condense at metaphase.

Original languageEnglish (US)
Pages (from-to)310-314
Number of pages5
JournalParasitology Today
Volume11
Issue number8
DOIs
StatePublished - Aug 1995

ASJC Scopus subject areas

  • Parasitology

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