First detection of TR34 L98H and TR46 Y121F T289A Cyp51 mutations in aspergillus fumigatus isolates in the United States

Nathan P. Wiederhold, Veronica Garcia Gil, Felipe Gutierrez, Jonathan R. Lindner, Mohammad T. Albataineh, Dora I. McCarthy, Carmita Sanders, Hongxin Fan, Annette W. Fothergill, Deanna A. Sutton

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86 Scopus citations

Abstract

Azole resistance in Aspergillus fumigatus is an increasing problem. The TR34 L98H and TR46 Y121F T289A mutations that can occur in patients without previous azole exposure have been reported in Europe, Asia, the Middle East, Africa, and Australia. Here, we report the detection of both the TR34 L98H and TR46 Y121F T289A mutations in confirmed A. fumigatus isolates collected in institutions in the United States. These mutations, other mutations known to cause azole resistance, and azole MICs are reported here.

Original languageEnglish (US)
Pages (from-to)168-171
Number of pages4
JournalJournal of clinical microbiology
Volume54
Issue number1
DOIs
StatePublished - Jan 2016

ASJC Scopus subject areas

  • Microbiology (medical)

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    Wiederhold, N. P., Gil, V. G., Gutierrez, F., Lindner, J. R., Albataineh, M. T., McCarthy, D. I., Sanders, C., Fan, H., Fothergill, A. W., & Sutton, D. A. (2016). First detection of TR34 L98H and TR46 Y121F T289A Cyp51 mutations in aspergillus fumigatus isolates in the United States. Journal of clinical microbiology, 54(1), 168-171. https://doi.org/10.1128/JCM.02478-15